H5 vaccine
- From: " Jill" <newsNOSPAM@xxxxxxxxxxxxxxx>
- Date: Fri, 24 Feb 2006 09:48:21 -0000
Vaccination against Avian Influenza
http://www.avian-influenza.com/control/introduction.asp
Lots more information available there
Advantages of Vaccination
Vaccination reduces susceptibility to infection.
A higher dose of virus is necessary to infect the vaccinated birds.
Vaccinated birds shed less virus.
Decreased contamination of the environment.
Decreased risk of human infection
Used strategically vaccination compliments a stamping out strategy by
slowing/stopping the spread of the virus
Reduction of Virus Excretion after Vaccination
Laboratory Trial
Day old chicks vaccinated with an inactivated avian influenza vaccine
containing strain H5N2.
4 weeks later the chickens were challenged with HPAI A/Hong Kong/156/97
(H5N1).
2 days post challenge it was demonstrated that the vaccinated birds shed
lower levels of the challenge virus than the unvaccinated birds. See figure
below.
For more information see:
Swayne D.E, Beck J.R, Perdue M.L, Beard C.W (2001)
Efficacy of vaccines in chickensagainst highly pathogenic Hong Kong H5N1
Avian Influenza.
Avian Diseases 45: 355-365
Field situation
Ellis et al. reported two field cases of H5N1 avian influenza in Hong Kong
from December 2002 to January 2003. Flocks were vaccinated with a
commercially available H5N2 vaccine. The authors concluded that in a field
situation vaccination not only stopped virus transmission, but there was
also no virus shedding from the remaining chickens.
See abstract : Vaccination of chickens against H5N1 avian influenza in the
face of an outbreak interrupts virus transmission
Trevor M. Ellis, Connie Y. H. C. Leung, Mary K. W. Chow, Lucy A. Bissett,
William Wong, Yi Guan, J. S. Malik Peiris
Perceived Disadvantages of Vaccination
Perceived disadvantage of vaccinationSolution
Not in line with OIE or EU control strategies.
Negative impact on trade agreements.
Clinical signs are reduced. Disease may be missed in a flock.
Vaccinated and naturally infected birds cannot be distinguished
Vaccination is accepted as control measure by the OIE
(International Animal Health Code, article 2.1.14.2)
See trade regulations
Non-vaccinated chickens can be placed in a flock to serve as sentinels.
Read more in Monitoring
More Information
Ilaria Capua, Stefano Marangon
The use of vaccination as an option for the control of Avian Influenza
71st General Session of the World Organisation for Animal Health, Paris,
18-23 May 2003
Commission decision 2004/666/EC (59Kb)
September 2004: Commission Decision to allow vaccination against H5 and H7
in Italy without trade restrictions for meat from vaccinated and AI-free
flocks.
View | Download
Vaccination as Part of an Avian Influenza Control Strategy (31Kb)
Johann Breytenbach.
A look at the advantages of including vaccination in an avian influenza
control strategy.
View | Download
Making Avian Influenza vaccines available, an industry point of view (280Kb)
Paul van Aarle
A look at how vaccination can help control avian influenza outbreaks when
used as part of a complete strategy. Also a discussion on how vaccines
containing new strains can be efficiently and quickly produced.
--
regards
Jill Bowis
Pure bred utility chickens and ducks
Housing; Equipment, Books, Videos, Gifts
Herbaceous; Herb and Alpine nursery
Working Holidays in Scotland
http://www.kintaline.co.uk
.
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