"DHEA may ...prevent diabetes during aging."
- From: James Michael Howard <jmhoward@xxxxxxxxxxxxxxxx>
- Date: Tue, 27 Dec 2005 15:51:45 GMT
FEBS Lett. 2005 Dec 20; [Epub ahead of print]
Dehydroepiandrosterone increases beta-cell mass and improves the
glucose-induced insulin secretion by pancreatic islets from aged rats.
Medina MC, Souza LC, Caperuto LC, Anhe GF, Amanso AM, Teixeira VP, Bordin
S, Carpinelli AR, Britto LR, Barbieri RL, Borella MI, Carvalho CR.
Department of Physiology and Biophysics, ICB, USP, Sao Paulo, SP,
CEP05389-970, Brazil.
The effect of dehydroepiandrosterone (DHEA) on pancreatic islet function of
aged rats, an animal model with impaired glucose-induced insulin secretion,
was investigated. The following parameters were examined: morphological
analysis of endocrine pancreata by immunohistochemistry; protein levels of
insulin receptor, IRS-1, IRS-2, PI 3-kinase, Akt-1, and Akt-2; and static
insulin secretion in isolated pancreatic islets. Pancreatic islets from
DHEA-treated rats showed an increased beta-cell mass accompanied by
increased Akt-1 protein level but reduced IR, IRS-1, and IRS-2 protein
levels and enhanced glucose-stimulated insulin secretion. The present
results suggest that DHEA may be a promising drug to prevent diabetes
during aging.
.
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