Testosterone and Coronary artery disease in women



(I think testosterone is involved in increasing obesity, cigarette smoking,
and coronary artery disease. JMH)

Pol Arch Med Wewn. 2006 Feb;115(2):118-24.

[Hyperandrogenism as a risk factor of coronary artery disease in young
women][Article in Polish]

Sablik Z, Samborska-Sablik A, Bolinska-Soltysiak H, Goch JH, Kula K.
Klinika Kardiologii i Katedry Kardiologii i Kardiochirurgii, Uniwersytet
Medyczny w Lodzi.

The aim of the study was an attempt to assess the relative roles of common
risk factors of coronary artery disease (CAD) and sex hormones in the
pathogenesis of CAD in young menstruating women. 38 women in the age of
35-47 years with past myocardial infarction and angiographically proven
critical changes in coronary arteries, with one-vessel disease in 22 women
(58%) or multi-vessel disease in 16 (42%) were examined. A referee group
consisted of 15 healthy women in the age of 35-45 years. In all women
multiple risk factors were searched, including value of body mass index
(BMI) and waist-hip ratio (WHR). In 4-7 day of sexual cycle at 8.00 a.m.
blood from cubital vein was taken to measure concentrations of biochemical
parameters and hormones: estradiol, testosterone (T),
dehydroepiandrosterone sulphate, folliclestimulating hormone, luteinizing
hormone, prolactin, thyreotropin, progesterone, cortisol and sex-hormone
binding globulin. In women with CAD, comparing to healthy ones, a higher
frequency of arterial hypertension (55% vs 7%), cigarete smoking (95% vs.
46%), hirsutism (84% vs. 30%) and dyslipidaemia was found. Concentration of
T was significantly higher in women with CAD than in healthy women (3.5 +/-
1.5 nmol/l--vs. 2.4 +/- 1.0, p < 0.014). In regression analysis was
revealed that in multiple parameters a cluster of 2 parameters,
dyslipidaemia and hirsutism, was of the best goodness of fit with occurence
of CAD. Significant relation with CAD was proven for visceral obesity,
eleveted concentration of T and cigarette smoking, either. Conclusions.
Apart from common known risk factors as visceral obesity, dyslipidaemia and
cigarette smoking it is hiperandrogenism that may participate in
pathogenesis of CAD in women in the reproductive age.


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