Re: Hamilton's Nonsense
From: Jim McGinn (jimmcginn_at_yahoo.com)
Date: 01/15/05
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Date: Sat, 15 Jan 2005 05:04:36 +0000 (UTC)
Joe Felsenstein wrote:
<snip>
> McGinn calculated the probability
> among all offspring,
Yes, because that was the issue under discussion:
Perplexed in Peoria stated:
"And the reason why this assumption simplifies
the derivation is that if the gene IS rare in
the population, then the probability that the
gene appears in the recipient is simply "r",
the probability that the gene was IBD."
> . . . whereas the question asked in kin
> selection arguments
Perplexed in Peoria made no such assertion.
Joe, you really should make more of an effort
to follow the thread.
<snip>
> In effect, McGinn got unconditional and conditional
> probability mixed up.
It's like talking to Edser. I get the feeling
like you don't fully comprehend what you are saying.
> > Uh, yeah, what's your point?
>
> (1) That McGinn's 0.10 figure was quite wrong,
No, Joe, my figure was quite right (and it
completely refutes your's, Josh's, and Peoria's
notion of IBD determines R in Hamiltion rule).
You cannot deny it.
> (2) that the true
> figure gets very close to the IBD number when
> the allele is rare.
.10 is not close to .50
The jig is up.
> > I don't disagree with what you are saying here.
> > Unfortunately it doesn't have much of anything to do
> > with the issue that Josh put forth. If you read back
> > through the thread this will be apparent to you.
>
> I'm glad to see that McGinn now agrees . . .
Desperation.
<snip>
Jim
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