Re: PIP in June
- From: "Perplexed in Peoria" <jimmenegay@xxxxxxxxxxxxx>
- Date: Sun, 28 Aug 2005 18:17:07 -0400 (EDT)
<TomHendricks474@xxxxxx> wrote in message news:derghu$1tjg$1@xxxxxxxxxxxxxxxxxxxxxx
> PIP in a June post said this about replication:
> But there is another solution. Anchor one strand to one membrane and
> the other strand to another membrane. Allow the two membranes to drift
> apart (or force them apart) and let mechanical forces unwind the helix.
> There are many different geometries which make this work. But all will
> result in the coupling of nucleic acid replication to the lipid
> reproductive cycle.
>
> Tom
> I have an easier way.
> The replicator will divide best inside the lipid.
Ok, but you are discarding my gimmick for unwinding the helix, so you
need some other gimmick.
> It continues to divide until the lipid is full of replicates.
> At some point the lipid would divide by itself and most
> likely have replicants in each half. Perhaps a build
> up of replicates may help pressure this first division.
> No matter, only later would they syncronize their efforts.
Something like that is the "standard" viewpoint. But it doesn't
really work to have random segregation of genes at cell fission.
If there are too few copies of each gene in the parent, then
the risk is too high that one of the daughters will be missing
a gene. If there are too many, then genes will compete within
the genome to maximize the number of copies, rather than
contributing to cell fitness.
The key paper on this was written in the late 1980s IIRC, and the
title was something like: "Origin of Life: Between Scylla and
Charibdis". Tim Tyler has posted some stuff about Eors Szathmary's
analysis of the problem.
My opinion is that the only solution to the problem is to have
accurate segregation from day one.
.
- References:
- PIP in June
- From: TomHendricks474
- PIP in June
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