Re: chromosome repair leading to expression of recessive genes?


"Laurens" <L.Witter@xxxxxxxxx> wrote in message news:dfn1kv$288k$1@xxxxxxxxxxxxxxxxxxxxxx
[snip]
> When an error occurs early in development, and it can not be repaired,
> a gene can shut down. The gene variant on the other chromosome can take
> over giving rise to a cell line with somewhat different properties. It
> can happen, though it is very rare. And yes, it can give some weird
> results. For example: I know someone with a radially extending dark
> spot on his iris. One cell has had a mutation and it has spread in that
> particular cell line.
>
> I hope my answer is understandable.
>
> Laurens
>
> melody_ann_ryan@xxxxxxxxx wrote:
>
> > I was reading this article talking about the future of the Y chromosome
> > and this paragraph interested me:
> >
> > http://www.npr.org/templates/story/story.php?storyId=4225769
> >
> > "All the other chromosomes come in two copies. Every time a cell
> > divides, mistakes in genes can creep in. In paired chromosomes, that
> > means that if there is a mistake on one chromosome, a cell can always
> > get the correct gene sequence from the other chromosome."
> >
> > Sorry if I am making a big misunderstanding, but it sounds to me that
> > when a gene on a chromosome is damaged, the chromosome will just repair
> > it with the gene on the other half of the chromosome. If there was a
> > gene pair where the dominant gene was damaged, would the cell (and all
> > of its offspring) then express the recessive gene? That could lead to
> > some wierd results if it happened early in development. Am I off base?

melody_ann,
Your understanding is correct. For another (common) example of a genetic
chimera try Googling on the words:
calico cat barr body


.

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