Re: Haldane's Dilemma - clarifications - and Felsenstein [LONG]


"Joe Felsenstein" <joe@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx> wrote in message news:e7cbcg$234r$1@xxxxxxxxxxxxxxxxxxxxxx
I'm not Walter, but do want to comment on the model. It's
a straightforward computer simulation of natural selection of
mutations, with a few wrinkles. I wonder if you don't want to
modify those wrinkles:
1. The alleles are either A or a. In this case the population will,
after enough generations, end with with mostly A's but some a's, as
there is back mutation at a rate equal to forward mutation. So it
will be approaching an asymptotic amount of adaptation. A useful
modification would be to have the alleles be integers which are not
just characters 'A' and 'a' but can be incremented. Thus we would have
alleles 0, 1, 2, ... and this would allow new alleles to be replaced by
even better alleles. Mutation would be incrementation of the integer.
Or if you wanted to have back mutation as well mutation could sometimes
increment and sometimes decrement. The resulting model would gain
favorable mutations (with some but not much loss as well) and this
would go on indefinitely, or at least until you got near MAXINT.

A great idea. If you decide to implement this, Malcolm, don't forget
to introduce a factor of sizeof(int) into your memcpy's in the
recombination code in the makechild function.


.

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