Re: Haldane's Dilemma and quantitative genetics


Perplexed in Peoria wrote:


But now we are in the genomic era, and there is some new evidence on
rates of selective substitution that may make the issue empirically
relevant again.

Since you're interested in this you should probably check out the data
on maize where the ancestral species teosinte still exist. I think you
could do a rough analysis with the numbers available today to see if it
falls within predicted ranges or not.

Here's an article on the effects of domestication/artificial selection
on 774 genes.

&itool=pubmed_docsum
From the article: "If we assume that our sample of genes is
representative, approximately 1200 genes throughout the maize genome
have been affected by artificial selection."

I'm reasonably sure that there is data for neutral substitutions,
population sizes, time to MRCA etc. to be had.

We shall see whether Haldane's dilemma studies emerge
in a new renaissance after 25 years of benign neglect.

:)


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