Re: The Cost of Substitution

In article <ejm80p$ie2$1@xxxxxxxxxxxxxxxxxxx>,
Malcolm <regniztar@xxxxxxxxxxxxxx> wrote:
"Walter ReMine" <science@xxxxxxxx> wrote in message
[his usual stuff]
I did my best to try to get you to say what this "cost of substitution"
actually is. If it is anything mathematical then it ought to be possible to
produce a computer model to demonstrate the effect. However there was no
joy.

Let's renew the discussion of the computer program. If we can get an
efficient version that allows multiple substitutions, and has a limited
"cost", we should be able to see whether we can verify ReMine's assertions
in that case. I think we came close to that starting point last time.

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Joe Felsenstein joe@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Department of Genome Sciences and Department of Biology,
University of Washington, Box 355065, Seattle, WA 98195-5065 USA

.