Re: Mutated brain gene: part of what makes us human

On May 11, 1:34 pm, d...@xxxxxxxxxxxxxxxxxxxxxxxxx (DK) wrote:
In article <f20bkd$186...@xxxxxxxxxxxxxxxxxxx>, d...@xxxxxxxxxxxxxxxxxxxxxxxxx (DK) wrote:
In article <f1t1qn$2cn...@xxxxxxxxxxxxxxxxxxx>, Tim Tyler
<seemy...@xxxxxxxxxxxxxx> wrote:
"Gene mutation linked to cognition is found only in humans"

-http://www.physorg.com/news97825267.html

OK, so humans have an additional splice isoform. Big deal.
Unless I missed something, there are many such examples.
Certainly a far cry from "part of what makes us human"
(unless you wanted to say "one part out of few thousands").

That "human and chimpanzee genomes vary by just 1.2 percent"
thing is getting old and overused anyway. Truth is, when one
looks at identity at protein/ORF level, humans and chimps only
have 80% identity. Or, to put it the other way, one out of five
proteins is different.

Actually, I was writing it from memory and my memory got
it all backwards. In fact, chimps and humans share only 20%
of *identical* proteins. The rest 80% are ever slighly but different.
Not to imply that every one contributes to phenotypic differnces
but, clearly, possibilities are endless. Here is the original paper:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubme...

Eighty percent of proteins are different between humans and chimpanzees
Galina Glazko, Vamsi Veeramachaneni, Masatoshi Nei, and Wojciech Makayowski

So, to edit it corectly:



Considering that a single mutation in a single protein can
drastically alter the way an entire cell or a whole organism
behave, the 80% difference looks appropriately very significant
and that "humans and chimps are 99% identical" - quite stupid.

DK

So we can't get organ transplants from chimps?


.

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