Re: Animation on Central Dogma

DK <dk@xxxxxxxxxxxxxxxxxxxxxxxxx> wrote:

In article <f7j3jb$28p8$1@xxxxxxxxxxxxxxxxxxx>, j.wilkins1@xxxxxxxxx (John
Wilkins) wrote:
Tim Tyler <seemysig@xxxxxxxxxxxxxx> wrote:

j_thomas wrote:

The central dogma of molecular biology was first enunciated by Francis
Crick in 1958 and re-stated in a Nature paper published in 1970.The
central dogma of molecular biology deals with the detailed residue-by-
residue transfer of sequential information. It states that such
information cannot be transferred back from protein to either protein
or nucleic acid.

http://bioisolutions.blogspot.com/2007/07/central-dogma.html

or

http://tinyurl.com/37qhfm

Ah, yes: the central dogma of pre-genetic engineering
molecular biology.

These are animations by my then-staff member Drew Berry of DNA
replication, transcription and splicing. He did this from original
papers and with the advice of scores of actual molecular biologists
including many genetic engineers. If you can fault any of it, feel free
to do so.

These are actually exceptionally good! On first view, I have only two
points of criticism:

1. Level of detail. It's a great fun for those who know the molecules
involved and understand rather well what's going on, but it's does
not seem to be particularly useful as an education tool (besides,
perhaps, conveying the message of complexity and directionality).

That's what happens when you have people like Jim Watson involved...

2. Translated protein folding is shown to be 100% autonomous. I
think it is pretty well established by now that most if not all
emerging peptides end up binding to one or more molecular
chaperone.

Well if he included *all* the molecules, you wouldn't see a damned thing
:-) If Drew ever does a folding animation, then I'm sure he'll have
chaperonins and such like in there too. But that comes under the generic
rubric of "proteomics" (-omics not involving DNA, anyway).

--
John S. Wilkins, Postdoctoral Research Fellow, Philosophy
University of Queensland - Blog: scienceblogs.com/evolvingthoughts
"He used... sarcasm. He knew all the tricks, dramatic irony, metaphor,
bathos, puns, parody, litotes and... satire. He was vicious."

.

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