Re: Gene duplication rate

On Sep 4, 4:15 pm, dkomo <dkomo...@xxxxxxxxxxx> wrote:
Lorentz wrote:
On Aug 30, 2:10 pm, dkomo <dkomo...@xxxxxxxxxxx> wrote:

Lorentz wrote:

On Aug 13, 1:20 pm, dkomo <dkomo...@xxxxxxxxxxx> wrote:

Duplications result from a phenomenon known as "unequal cross-over"
which occurs during meiosis of eukaryotic cells. This is a chance event
which happens when two homologous chromosomes misalign before they cross
over, resulting in one chromosome getting a redundant stretch of DNA.

And the other chromosome getting a reduced stretch of DNA. If you
include gene duplications, then you have to include gene deletions. A
gene deletion has about the same chances of being advantageous or
disadvantageous as a gene duplication. If the rates are roughly equal,
then the average genome size won't change.

I don't agree here. I think a gene deletion is far more likely to lead
to a dysfunctional organism than a gene duplication.

For a large genome, for a multiallelle phenotype, it seems to me
the outcome would be very similar.

Having an extra
gene probably doesn't have much effect if the regulation of that gene is
still intact.

Every gene has a switch for regulation and a coding part that
defines the residue sequence for the protein. By regulation intact, I
think you mean that the switch has not mutated. So lets look at the
nonmutated, the duplicated, and the deleted conditions.
No mutation. The gene waits until the right transposition factor
triggers the switch.

What's a transposition factor? Don't you mean "transcription factor"?
Err, yes.

Until then it does nothing. When the translation

factor activates the switch, RNA gets created in the sequence
determined by the code portion.

I think you're getting your terms confused. Translation factors act on
the processed mRNA transcripts in eukaryotes to prevent these
transcripts from attaching to ribosomes and getting translated.
Transcription factors actually control the transcription from the DNA
into primary DNA transcripts.
I apologize.



.

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