Re: Paper: Adaptive Evolution of Conserved Noncoding Elements in Mammals


"John W Edser" <edser@xxxxxxxxxxxxxx> wrote:
"Perplexed in Peoria" <jimmenegay@xxxxxxxxxxxxx> wrote:-
The CNCs show the signature of purifying selection by this very simple
test.
Extremely strong purifying selection. Hence, I doubt that Moran or anyone
else would call them junk.

JE:-
CNC's drift more than the coding part.

Hmmm. I'm pretty sure that is not true. Though it probably depends on
which CNCs you are talking about. There are some CNCs that are called
Ultra-Conserved Regions (UCRs) and those drift far less than typical
coding regions. Of course, some coding regions are also Ultra-Conserved.


.

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