Symmetry of DNA replication

Given a double strand of DNA, it seems at first sight that the replication
process could start just as easily at one end as the other. Does this
actually happen in cell division? That is, is each end equally likely to be
the starting point or is there a preferred (or only) direction? What about
circular DNA - is there a preferred way to go round during replication?

The reason for asking is that if there is a symmetry, it puts a constraint
on the pattern of mutations that can arise.

Graham Jones



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