Green Fluorescent Protein(GFP)[ Nobel Prize 2008]

Green florescent protein (GFP) has revolutionized research in medicine
and biology, enabling scientist to get a visual fix on how organs
function on the spread of disease and the response of infected cells
to treatment,GFP has a typical beta barrel structure, consisting of
one =E2-*** with a alpha helix containing the fluorophore running
through the center, while the tightly packed barrel shell protects the
flurophore from quenching by the surrounding microenviornment,the
inward facing side chains of the barrel induce specific cyclization
reactions on the tripeptide Ser65-Tyr66-Gly67 that lead to fluorophore
formation. This occurs in a series of discrete steps with distinct
excitation and emission properties.

In 2008 Nobel Chemsitry prize was announced to Osamu Shimomura of
Japan and American duo Martin chalfie and Roger Tsien for deriving
Florescent protein from a jellyfish Aequorea Victoria.

http://bioisolutions.blogspot.com/2008/10/green-fluorescent-proteingfp.html

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