Penicillin Binding Protein Animation

Penicillin-binding proteins (PBPs) are a group of proteins that are
characterized by their affinity for and binding of penicillin. They
are a normal constitutent of many bacteria;All beta-lactam antibiotics
bind to PBP to have their effect of preventing cell wall construction
by the bacterium.There are a large number of PBPs, usually several in
each organism, and they are found as both membrane-bound and
cytoplasmic proteins. For example, Spratt (1977) reports that six
different PBPs are routinely detected in all strains of E. coli
ranging in molecular weight from 40000 to 91000. The different PBPs
occur in different numbers per cell and have varied affinities for
penicillin . The PBPs are usually broadly classified into high-
molecular-weight (HMW) and low-molecular-weight (LMW) categories.

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