morphine ; resistance of — to putrefaction

From: donald j haarmann (donald-haarmann_at_worldnet.att.net)
Date: 08/28/04 

Date: Sat, 28 Aug 2004 09:23:38 GMT

Once again — the WHAT — but not the why!!

Resistance of Morphine to putrefaction.
F. Doepmann.
Chem.-Zeit., 1915, 39,69-71.

In — The Journal of the Society of Chemical Industry.
34 [6] 300. March 31, 1915.

Separate quantities of 1 kilo. of chopped, lean horseflesh were mixed with 200,
100, 50, and 20 mgrms. respectively of morphine hydrochloride and 200 grms. of
the mixture investigated after 1, 2 ½, 5 ½, and 11 months. The putrefying mass
was thoroughly extracted with very dilute acetic acid, first cold, then warm, and
finally on the water-bath. The acid extract was concentrated, precipitated with
alcohol, the alcohol-free filtrate precipitated with lead acetate, excess of lead
removed by hydrogen sulphide, and the solution concentrated, made alkaline
with ammonia, and extracted repeatedly with warm chloroform. The residue form
the chloroform extract was dissolved in dilute sulphuric acid and extracted with
pure amyl alcohol to remove colouring matters, then made alkaline with caustic
soda, and extracted with a small amount of chloroform to remove ptomaine
bases, and finally made alkaline with ammonia and repeatedly extracted with
warm chloroform. The pale yellow varnish left on evaporating the chloroform
gave in every case the characteristic reactions of morphine. 

-- 
donlad j haarmann
------------------------------
Eventually we eliminated all flaws, using the method of proof by
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Nature 428, 261 (2004)
On Savas Dimopoulos and his work on supersymmetry.