Re: Ammonium Salicylate

From: hanson (hanson_at_quick.net)
Date: 11/03/04 

Date: Wed, 03 Nov 2004 18:09:03 GMT

"Dirk Bruere at Neopax" <dirk@neopax.com> wrote in message
news:2uqs2kF2e3ph5U1@uni-berlin.de...
Can anyone tell me anything useful about Ammonium Salicylate?
AmSal Properties?
Can't find MSDS on the Net.
Has it medicinal uses?
Seen it as an ingredient on a bottle of suntan lotion,

[Don Haarmann]
[AmSal] it is not harmful/hazardous to two legged carbon units
there will be no MSDS. --- Merck's Index says:-
A.- Antriheum.; Antipyr.; Germic; Expector. -
Uses : In febrile conditions, bronchitis, artic. rhumat., &c. -
Dose 2-20 grains (0.2-1.3 Gm.) in wafers.
>
[Dirk]
> I was wondering whether it [AmSal] might be formed on/in
> the skin when (say Cu Salicylate is applied topically. And
> whether there may be benefits from using it on its own.
> Dirk
>
[hanson]
It is highly unlikely but not impossible that
CuSal + SkinProteinNH2 ---> NH4Sal
Not impossible, because Merck Index 13 says that AmSal is an
analgesic and is used as "topically to loosen psoriatic scales".
This is right up the alley of your research application.
So, give AmSal a try without the Cu in it. Now, you have also
reported some success with Cu-chelates/CuSal. Therefore try
also Cu(NH3)2-Sal or Cu(NH3)4-Sal and similar combos.
The more Ammonia the higher the alkalinity, so caution.
Their solubility you must find by experiment.
Be aware that, as was posted, the light sensitivity of AmSal
may cause a stability problem. Naturally, the Cu is the mix
will enhance this, in addition with the Cu's propensity to form
radicals. Radicals are a two etched sword. They may multiply
the clinical properties you look for but side effects may outweigh
the gain. Check it out.
hanson