Re: Thiol FG transformation

From: adonald@xxxxxxxxxxxxxxxxxxxxxx (Alastair)
Date: 29 Apr 2005 07:25:57 -0700

> > React (heat) the alkyl halide with thiourea to give the S-alkyl
> > isothiuronium chloride, then base to hydrolyse it to the thiol. Might
> > need a bit of iodide to get it going.
> >
> > http://www.oxfordchemicals.com/oxford/ocweb.nsf/web%20pages/Sulphur2/$Fi
> > le/sulphurpart2.pdf?OpenElement

Or...try displacement using potassium salt of thioacetic acid, then hydrolyse.
.

References:
- Thiol FG transformation
  - From: Dave
- Re: Thiol FG transformation
  - From: Chris Cooksey
- Re: Thiol FG transformation
  - From: Dave

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