Re: How would you test temporary pain relief tablets in the lab to see which one dissolves quickest into the bloodstream?
- From: War Office <911falseflag@xxxxxxxxx>
- Date: 28 Apr 2007 08:59:24 -0700
On 28 abr, 12:41, War Office <911falsef...@xxxxxxxxx> wrote:
On 27 abr, 01:32, missw...@xxxxxxxxxxx wrote:
Hello I am Shaniya
I am Year 11 student from Alfriston College. I am currently doing a
science experiment investigating which temporary pain relief is
absorbed the quickest in your body providing you with efficient
relief. So what I am Really trying to do is recreate the stomach
conditions in the lab of 2-3pH. With the chemicals mainly consisting
of HCl and a bit of KCl and NaCl and pepsin, but i dont really know
what the EXACT amount of these should be as i would like to carry the
experiment out in a test-tube. any other ideas of what important
chemicals i could use would be very helpful in relation to things that
would be important for the absorption of a pain relief such as
panadol. i would also like to know if i were to be stirring the
solution with the tablet, on what intervals would be the best time and
why? And just in the whole any feedback about this experiment and any
improvements you could make would be well recieved.
Thank You hope to hear from you soon
Look up blood-brain-barrier and specific-site drug delivery. This
question is more of a biomedical, pharmacologlical area of expertise.
But the two key terms I've given you will get you extra marks I'm
guessing.
Sorry I couldn't help more.
There are many considerations to this object:
For example read the following innovations in your above problem
matrix:
""Nanotechnology is the key to optimizing drug delivery," said Dr.
Roger Aston, Director of Strategy at pSivida Limited in Australia. "By
presenting drugs at the nanoscale, the immediate impact is making
otherwise poorly soluble drugs much more bioavailable, soluble, and
safer."
Just about half of all new chemical entities are insoluble, thus
improving solubility and bioavailability is the first principal aim of
nanotechnology. The second is to enhance release characteristics.
In addition to improved solubility, drugs based on nanotechnology have
several other advantages over those developed by other means,
according to the Institute of Nanotechnology in Glasgow, Scotland. For
example, drugs tend to perform better in nanoparticulate form as the
drugs perform more efficiently and with fewer side effects. And,
specific nanosized receptors present on the surface of cells will
recognize the drug and elicit an appropriate response, thus delivering
and releasing the therapeutic exactly where needed."
http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=256
Have you covered the topic at all in lectures? This would indicate a
simplistic model that the teacher wants you to apply. At Year 11 level
science you'll be learning basic stoichiometric, solubility
coefficients etc..which may afford you to totally overlook reality for
sake of feigning a "Real World" problem.
The problem you mention is rather complex as you now see.
There are also other issues. For example like Donald Rumsfeld directed
as head of this company producing Aspartame, rather than test the
solubility and conduct thorough clinical trials you could just bribe
authorities to green-light the product anyways. Often in the real
world the game of profiteering is more important than Science.
http://www.prisonplanet.com/articles/april2006/050406goodforyou.htm
Or like with another company I worked for, rather than work out how to
safely manufacture Chromic Acid you could just pour the residue acid
down the storm-water drain by outsourcing the job to a smaller company
which would take the blame if the EPA caught them., which is what
AtoTech used to do.
Outsourcing is another very important part of Science which isn't
being taught properly at schools or Univerisities.
Perhaps you should write to Martin Utteridge, Managing Director of
Atotech Australia / New Zealand and ask him if it would be better to
construct your experiement by cheating and dumping extremely toxic
environmentally devestating chromic acid residue down the storm water
drain:
http://www.atotech.com/start.php3?cl_my_id=705590
He would no alot about Outsourcing as a means to protect your company
from environmental terrorism charges.
Also an essential equipment for any good commercial research
laboratory is a black-op hit squad to take out any would-be
whisteblowers as well as a clandestine Industry Black-List so that any
career scientist ever considering speaking out will also consider
Bankruptcy and their house mortgage.
Perhaps your question is better directed to Donald Rumsfeld - the true
grandmaster of msas murder and environmental terrorism
Welcome to the Real World babe. Its ugly from here on in.
.
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