Re: Desperately seeking method.


"Bruce Sinclair"
<bruce.sinclair@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx>
wrote in message
news:fcaj0d$18d$1@xxxxxxxxxxx
In article
<fcahb6$55g$1@xxxxxxxxxxxxxxxxxxxx>, "Peter
Jason" <pj@xxxxxxxxxx> wrote:
To synthesize methyl glycine.

Please help.

Isn't that just alanine ?
Why not buy it ? ... or perhaps an enzymic
method might do it for you ? :)

If it's homework, best work out what you've
got and what reactions you've
recently covered. :) :)

Thanks, but I found it in some obscure site,
Vis:

*****

Glycine methyl ester is prepared by the
method of Almeida et al.3



In a mortar and pestle, 80 g of glycine
methyl ester hydrochloride (used as received
from Aldrich Chemical Company, Inc.) is
ground to a fine powder.



The powder is suspended in 600 mL of dry
ether in a 1-L Erlenmeyer flask equipped with
a Teflon-coated magnetic stirring bar.



Gaseous ammonia is bubbled rapidly through
the vigorously stirred suspension.



After 2 hr, the addition of ammonia is
discontinued, the product slurry is filtered
through a coarse-fritted glass filter, and
the filtrate is concentrated under reduced
pressure at 23°C.



The liquid residue is distilled under reduced
pressure (54-55°C at 18 mm) to provide 51.3 g
(90%) of glycine methyl ester as a colorless
liquid.



Glycine methyl ester will polymerize upon
storage at room temperature, but may be
stored at ?20°C for short periods (up to two
weeks) without significant decomposition.



*****


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