Re: "Statins caused my kidney failure"

From: Zee (zwalanga_at_yahoo.com)
Date: 07/14/04 

Date: 14 Jul 2004 09:47:19 -0700

"Bill" <xxx@yy.zz> wrote in message news:<GI3Jc.1762$ii.888@newssvr32.news.prodigy.com>...
> "Zee" <zwalanga@yahoo.com> wrote in message
> news:e5f4a9c2.0407131650.5c78be4a@posting.google.com...
> > peterc_7@hotmail.com (Pete C.) wrote in message
> news:<25e68f26.0407130527.3c37f93e@posting.google.com>...
> > > "Don" <Don12345@supportcharter.net> wrote in message
> news:<10f5i5tpaao9e5c@corp.supernews.com>...
> > > > You are talking about Simvastatin and Lipitor.
> > > >
> > > > I did some research and Simvastatin is Zocor.
> > > >
> > > > Lipitor is Atorvastatin
> > > >
> > > > I'm confused. Maybe someone can please help.
> > > >
> > > > I'm taking Lipitor (Simvastatin).
> > > >
> > > > Don
> > >
> > > If you're taking Simvastatin then you are taking Zocor. Don't listen
> > > to the BS stories about statins. Your doctor will follow up with some
> > > blood tests to make sure the statin you are taking is not causing
> > > problems and is helping to lower your cholesterol.
> >
> >
> > Don
> >
> > Pete C must not be aware that statin induced mitochondrial myopathy
> > can occur independent of elevated CK levels. Ie) not detectible in a
> > blood test.
> > http://www.impostertrial.com/physician.htm
> >
> >
> > Pete:
> >
> > Perhaps you should inform yourself of the facts before you give out
> > erroneous information about how statins' toxic effects are detected.
> >
> > You may also want to know these disabling and life-altering effects
> > not detectible by the tests you mention do not always go away.
>
> I'm not sure of that. In the site above and associated article, it seems the
> four patients they talked about reversed. And I think that is all Golomb
> relied upon for information on people with negative CK tests.
>
> > In fact
> > the researcher/cardiologist whose website this is has people still
> > with mitochondrial myopathy up to four years after stopping them. He
> > will be publishing *another* couple studies on this topic this fall.
> > You can find his existing studies on Annals of Internal Medicine, and
> > www.pubmed.org.
> >
> > Phillips says only half of those in his study who had statin-induced
> > rhabdomyolysis had complete remission of symptoms. Those reporting, of
> > course, were the ones who lived.
> >
> >
> >
> >
> > "http://www.geriatrictimes.com/g040618.html
> > This article comes with a long list of citations from peer-reviewed
> > journals.
> >
> > "Physicians are most familiar with rhabdomyolysis, and many suppose
> > that for muscle pain to be statin-associated, it must induce muscle
> > symptoms throughout the body coupled with elevation of CK levels.
> > However, this reflects only one manifestation of statin-associated
> > muscle symptoms. Some patients have only new focal pain or new
> > fatigue, and may have mild or no elevation in CK levels. In some
> > instances these symptoms progress to rhabdomyolysis--one reason to
> > take these symptoms seriously--but many times they do not."
> >
> > An important double-blind, crossover biopsy study showed that some
> > patients receiving statin therapy with non-CK-elevating muscle pain
> > have objectively documentable, partially reversible mitochondrial
> > myopathy (Phillips et al., 2002). Even in the absence of
> > rhabdomyolysis or CK elevation, major effects on function and quality
> > of life may occur (Golomb et al., 2003). It is important to note that
> > in both our experience and that of others, muscle symptoms
> > precipitated by statins may not in all cases completely recover; this
> > is consistent with the finding that, pathologically, the myopathy may
> > not completely reverse. more...."
> >
> >
> >
> > This study was done by the non-industry funded epidemiology group
> > Therapeutics Initiative (TI).
> >
> > http://www.ti.ubc.ca/pages/letter48.htm
> > Conclusions:
> > If cardiovascular serious adverse events are viewed in isolation, 71
> > primary prevention patients with cardiovascular risk factors have to
> > be treated with a statin for 3 to 5 years to prevent one myocardial
> > infarction or stroke.
> >
> > This cardiovascular benefit is not reflected in 2 measures of overall
> > health impact, total mortality and total serious adverse events.
> >
> > ***Therefore, statins have not been shown to provide an overall health
> > benefit in primary prevention trials.***
> >
> >
> >
> >
> > In this article, Dr. James Wright, head of TI, has more non-industry
> > funded comments on statins.
> >
> >
> http://www.newsday.com/news/health/ny-dsrabin3881826jul06,0,473904,print.column
> >
> > Last year, scientists at the University of British Columbia's
> > Therapeutics Initiative came to a similar conclusion about the use of
> > statins in men who didn't have prior heart disease. Sure, they had
> > fewer heart attacks - but they still died at the same rate. "What
> > we're hypothesizing is that there was some other harm" associated with
> > the medication, said Dr. Jim Wright, the clinical pharmacologist who
> > did the study, funded entirely by a grant from British Columbia's
> > health department. "That really should concern people."
> >
> > "Before we prescribe this to millions of people who are basically
> > healthy, we should be proving that the overall benefits outweigh the
> > harms," he said. "And we don't think that's the case."
> >
> >
> > Zee
>
> For the moment, I agree with that except for, perhaps, for diabetics due to
> the recent study.
>
> But to be fair, you should also cite the following comment from your final
> source:
>
> Statins provide a cardiovascular and total mortality benefit for patients with
> clinically evident occlusive vascular disease (secondary prevention) and a
> cholesterol of >3.5 mM.
>
> http://www.ti.ubc.ca/pages/letter49.htm
>
> Bill

It doesn't apply to the OP, who is using zocor preventively. I also
didn't cite the hundreds of studes showing various kinds of statin
toxicity, including the eye damage four other ops here in a recent
different thread mentioned, and from which I have had irreparable
vision damage.

No. There are not only 4 who's statin induced mitochondrial myopathy
is provable. The four are from the 2002 article published in Annals of
Internal Medicine "Statin induced mitochondrial myopathy independent
of elevated CK..."

The people documented on www.impostertrial.com/histopathology.htm
showed pathology long after stopping, in muscle biopsy. These few were
not few from thousands, but few presenting themselves to test, and
used as indicator for further funding to continue the study, which
will be published this fall.

However, I have them. And you don't. So I can see you'd be handicapped
here. But for a keen scent hound like you, the scat from this whole
stinking mess is there.

Zee

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