Re: Lp (a)

From: Zee (zwalanga_at_yahoo.com)
Date: 07/15/04 

Date: 15 Jul 2004 13:36:45 -0700

Brad@sheppardsoftware.com (Brad Sheppard) wrote in message news:<b06e736a.0407150629.77a73cab@posting.google.com>...
> Marcie,
> Besides Lp(a) your numbers are excellent. What I'd suggest is 1) take
> the NIH risk calc. http://hin.nhlbi.nih.gov/atpiii/calculator.asp?usertype=pub
> 2) try some dietary/exercise changes - take another quiz from Harvard
> that gives dietary/exercise advice
> http://www.yourdiseaserisk.harvard.edu/hccpquiz.pl?func=start&quiz=heart
> 3) tell your doc your trying to modify your diet to see if it makes a
> difference. 4) or ask your doc, given your low calc risk, why take
> the drugs? Exception: if you have other risk factors - obesity,
> smoking, diabetes, family history, high blood pressure, etc.

Marcie

"The risk for total mortality was not lower in women treated with
lipid-lowering drugs, regardless of whether they had prior
cardiovascular disease or not," Dr. Judith M.E. Walsh and Dr. Michael
Pignone wrote.

We've been bamboozled' about cholesterol risks
Roni Rabin
    
http://www.newsday.com/news/health/ny-dsrabin3881826jul06,0,473904,print.column
July 6, 2004

If you're a woman like me who worries about your blood cholesterol
level, there's something you should know.

Buried in the back pages of a leading medical journal recently was a
study that raised serious questions about whether cholesterol-lowering
drugs are useful for women who are otherwise healthy.

The study didn't get a lot of media attention. But its results were
surprising - especially considering how many millions of women are
taking drugs known as statins to lower their cholesterol. Women like
me, who've had it drummed into us that heart disease is the leading
cause of death we face. And who've been told repeatedly cholesterol is
a major risk factor.

The paper, published in the Journal of the American Medical
Association, examined the results of 13 carefully selected clinical
trials and teased out the effects on women. It wasn't easy: At least
80 percent of the participants were men.

The researchers found that for women who are taking statins as a
preventative measure - they've never had cardiovascular disease but
may be at risk - it wasn't clear the pills bestowed any benefit.
That's because so few women in this group have heart attacks to begin
with.

For women who have cardiovascular disease, the drugs reduced the risk
of another heart incident - but did not reduce overall deaths.

"The risk for total mortality was not lower in women treated with
lipid-lowering drugs, regardless of whether they had prior
cardiovascular disease or not," Dr. Judith M.E. Walsh and Dr. Michael
Pignone wrote.

Last year, scientists at the University of British Columbia's
Therapeutics Initiative came to a similar conclusion about the use of
statins in men who didn't have prior heart disease. Sure, they had
fewer heart attacks - but they still died at the same rate. "What
we're hypothesizing is that there was some other harm" associated with
the medication, said Dr. Jim Wright, the clinical pharmacologist who
did the study, funded entirely by a grant from British Columbia's
health department. "That really should concern people."

"Before we prescribe this to millions of people who are basically
healthy, we should be proving that the overall benefits outweigh the
harms," he said. "And we don't think that's the case."

Health consumer advocates, such as Maryann Napoli of the Center for
Medical Consumers, have expressed concerns about statins, which have
been linked to muscle problems, including a rare condition that can be
fatal. The FDA banned Baycol in 2001; last week, Public Citizen's
Health Research Group called for banning Crestor.

The drugs do reduce blood cholesterol levels. But the relationship
between high cholesterol and heart disease is not so simple,
especially for women. The landmark Framingham heart study found that
in the vast majority of people, there was no difference in blood
cholesterol levels between those who developed heart disease and those
who did not. The only strong association between heart disease and
elevated cholesterol was found in young and middle-aged men - not
women - and it receded with age.

Still, the American Heart Association recommends aggressive treatment
to lower cholesterol in women, especially if other risk factors are
present, according to Dr. Nieca Goldberg, chief of the Women's Heart
Program at Lenox Hill Hospital in New York and a spokeswoman for the
AHA.

And when doctors talk about heart disease risks for women, they
mention high cholesterol in the same breath as high blood pressure,
diabetes, obesity, smoking and family history.

Wright, the Canadian researcher, suggests a distinction should be
made. "The weakest risk factor is cholesterol," he said. "The
correlation is extremely weak and even becomes negative as you get
older." He said the message about cholesterol has been distorted.

"We've been bamboozled," he said.

Dr. Beatrice Golomb, an assistant professor of medicine at the
University of California at San Diego who has done research on
cholesterol and statins, says no study has ever demonstrated that
statins extend life for women. "The people who benefit are middle-aged
men who are at high risk or have heart disease ..." she said. "The
mortality benefits don't extend to the elderly or to women."

Yes, heart disease is the leading cause of death in women - but only
when women 75 and older are included in the figures. Take those women
out and the picture changes.

Younger women know that, intuitively. It's misleading to scold them
for worrying too much about cancer and not enough about heart disease.
For women ages 35-74, cancer is the No. 1 threat, killing almost twice
as many women as heart disease, according to national statistics.

So if your doctor recommends a statin, ask about the side effects.
Find out if you have other risk factors for heart disease that justify
the medication. Male or female, "assume any new symptom you develop
after starting any new drug is caused by the drug," says Dr. Sidney
Wolfe, of Public Citizen. Report muscle aches, pain, tenderness or
weakness, and cognitive changes, and the sooner the better, Wolfe
says.

And make sure to tell the doctor what drugs you take.
Copyright © 2004, Newsday, Inc.

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