Re: Statin - CoQ10 suppression (Arch Neurol, 6/04)

From: John Merlano (someone_at_home.somewhere)
Date: 09/21/04 

Date: Tue, 21 Sep 2004 10:44:18 -0400

On Sun, 19 Sep 2004 04:58:44 GMT, Sharon Hope wrote:

Doesn't supplementing with CoQ10 help solve the problem of statins
preventing the body from making it? Something like 100 mg of CoQ10 in
softgel form?

> Hardly a surprise finding. The body creates CoQ10 in the mevalonate
> pathway. Statins interrupt this pathway upstream of the CoQ10 production.
> This short-circuiting of the process makes it impossible for the body to
> produce this nutrient that is so essential to the mitochondria.
>
> Such study findings are roughly equivalent to "when the faucet turns off,
> the water flow stops." Necessary to measure the absence of the water,
> though, for all those who will doubt it.
>
>
>
> "ChuckMSRD" <chuckmsrd@aol.com> wrote in message
> news:20040918065726.15331.00000665@mb-m22.aol.com...
>> 1: Arch Neurol. 2004 Jun;61(6):889-92. Related Articles, Links
>>
>>
>> Atorvastatin decreases the coenzyme Q10 level in the blood of patients at
> risk
>> for cardiovascular disease and stroke.
>>
>> Rundek T, Naini A, Sacco R, Coates K, DiMauro S.
>>
>> Department of Neurology, Columbia University College of Physicians &
> Surgeons,
>> New York, NY 10032, USA.
>>
>> BACKGROUND: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase
>> inhibitors) are widely used for the treatment of hypercholesterolemia and
>> coronary heart disease and for the prevention of stroke. There have been
>> various adverse effects, most commonly affecting muscle and ranging from
>> myalgia to rhabdomyolysis. These adverse effects may be due to a coenzyme
> Q(10)
>> (CoQ(10)) deficiency because inhibition of cholesterol biosynthesis also
>> inhibits the synthesis of CoQ(10). OBJECTIVE: To measure CoQ(10) levels in
>> blood from hypercholesterolemic subjects before and after exposure to
>> atorvastatin calcium, 80 mg/d, for 14 and 30 days. DESIGN: Prospective
> blinded
>> study of the effects of short-term exposure to atorvastatin on blood
> levels of
>> CoQ(10). SETTING: Stroke center at an academic tertiary care
> hospital.Patients
>> We examined a cohort of 34 subjects eligible for statin treatment
> according to
>> National Cholesterol Education Program: Adult Treatment Panel III
> criteria.
>> RESULTS: The mean +/- SD blood concentration of CoQ(10) was 1.26 +/- 0.47
> micro
>> g/mL at baseline, and decreased to 0.62 +/- 0.39 micro g/mL after 30 days
> of
>> atorvastatin therapy (P<.001). A significant decrease was already
> detectable
>> after 14 days of treatment (P<.001). CONCLUSIONS: Even brief exposure to
>> atorvastatin causes a marked decrease in blood CoQ(10) concentration.
>> Widespread inhibition of CoQ(10) synthesis could explain the most commonly
>> reported adverse effects of statins, especially exercise intolerance,
> myalgia,
>> and myoglobinuria.
>>
>> PMID: 15210526 [PubMed - indexed for MEDLINE]

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