Re: Statin - CoQ10 suppression (Arch Neurol, 6/04)

From: Zee (fresh~horses_at_despammed.com)
Date: 09/21/04 

Date: 21 Sep 2004 09:11:37 -0700

listener wrote:
> John Merlano <someone@home.somewhere> wrote in
> news:cxzmx31k31l6.zdz691du4415.dlg@40tude.net:
>
> > On Sun, 19 Sep 2004 04:58:44 GMT, Sharon Hope wrote:
> >
> > Doesn't supplementing with CoQ10 help solve the problem of statins
> > preventing the body from making it? Something like 100 mg of CoQ10
in
> > softgel form?
>
>
> From:
> http://faculty.washington.edu/ely/coenzq10.html
>
> "HMG-CoA reductase inhibitors used to treat elevated blood
cholesterol
> levels by blocking cholesterol biosynthesis also block CoQ10
biosynthesis
> (13). The resulting lowering of blood CoQ10 level is due to the
partially
> shared biosynthetic pathway of CoQ10 and cholesterol. In patients
with
> heart failure this is more than a laboratory observation. It has a
> significant harmful effect which can be negated by oral CoQ10
> supplementation(14)."
>
> L.

"In patients with heart failure."

These studeis deal with cardiomyopathy. Statin induced coenzyme q10
depletion is thought to have a far greater scope.

There is nothing yet regarding generalized myopathy. Or cognitive
adverse effect, or polyneuropathies, or....

Zee