DHEA and Increased Homocysteine in Pathology
From: James Michael Howard (jmhoward_at_anthropogeny.com)
Date: 11/14/04
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Date: Sun, 14 Nov 2004 17:43:15 GMT
DHEA and Increased Homocysteine in Schizophrenia and Other Mental and
Physical Disorders and Declines
Copyright 2004, James Michael Howard, Fayetteville, Arkansas, U.S.A.
Increased homocysteine has been connected with a number of
pathological conditions within us, other than mental illness. I
developed the following explanation in terms of schizophrenia. I
suggest the explanation may also fit other pathologies such as heart
conditions, such as cardiopathy, etc.
It is my hypothesis that schizophrenia results from low
dehydroepiandrosterone (DHEA) in utero / neonatal. This results in
reduced growth and development of the brain. Subsequently, the
hormones cortisol (stress) and testosterone in both sexes (puberty),
alone but most likely in combination, combine to reduce DHEA at the
time when DHEA naturally begins to decline around age twenty. This
then exposes, and further damages the reduced development of the brain
of early life, and causes the symptoms of schizophrenia to begin and
usually worsen with time. Low DHEA is a characteristic of
schizophrenia.
Applebaum, et al., (J Psychiatr Res. 2004 Jul-Aug;38(4):413-6) report
that "Homocysteine levels were markedly increased in this population
of newly admitted schizophrenic patients, especially in young males."
It is important to my hypothesis regarding low DHEA in schizophrenia,
and other mental disorders and declines, that Bednarek-Tupilowska and
Tupilowski reported that "Individual data showed that
dehydroepiandrosterone probably lowers Hcy [homocysteine] level."
(Postepy Hig Med Dosw (online) 2004; 58: 381-9. It should also be
noted that cortisol and testosterone both raise homocysteine levels,
also supporting my hypothesis.
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