Re: Question about Hypertension & Diabetes?

From: Dr. Andrew B. Chung, MD/PhD (nospam6_at_heartmdphd.com)
Date: 12/02/04 

Date: 2 Dec 2004 10:11:19 -0800

lordshiva5753@rediffmail.com (Kumar) wrote in message news:<13b3b038.0412010035.272b0d65@posting.google.com>...
> "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41AC61CE.4CAC@heartmdphd.com>...
> > Kumar wrote:
> > >
> > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A9C761.67ED@heartmdphd.com>...
> > > > Kumar wrote:
> > > > >
> > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A8834E.7878@heartmdphd.com>...
> > > > > > Kumar wrote:
> > > > > > >
> > > > > > > "Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A72836.70DC@heartmdphd.com>...
> > > > > > > > Herman Rubin wrote:
> > > > > > > > >
> > > > > > > > > In article <13b3b038.0411241901.4cef5120@posting.google.com>,
> > > > > > > > > Kumar <lordshiva5753@rediffmail.com> wrote:
> > > > > > > > > >"Dr. Andrew B. Chung, MD/PhD" <andrew@heartmdphd.com> wrote in message news:<41A49614.BD431EB7@heartmdphd.com>...
> > > > > > > > > >> Kumar wrote:
> > > > > > > > >
> > > > > > > > > ...................
> > > > > > > > >
> > > > > > > > > >quote:
> > > > > > > > > >--------------------------------------------------------------------------------
> > > > > > > > > >More commonly, people will develop insulin resistance (Type 2
> > > > > > > > > >Diabetes) rather than a true deficiency of insulin. In this case, the
> > > > > > > > > >levels of insulin in the blood are similar or even a little higher
> > > > > > > > > >than in normal, non-diabetic individuals. However, many cells of Type
> > > > > > > > > >2 diabetics respond sluggishly to the insulin they make and therefore
> > > > > > > > > >their cells cannot absorb the sugar molecules well. This leads to
> > > > > > > > > >blood sugar levels which run higher than normal. Occasionally Type 2
> > > > > > > > > >diabetics will need insulin shots but most of the time other methods
> > > > > > > > > >of treatment will work.
> > > > > > > > > >http://www.endocrineweb.com/diabetes/2insulin.html
> > > > > > > > > >--------------------------------------------------------------------------------
>
> > > > > > > > > >Under above consideration, I do not understand why oral hypogymic
> > > > > > > > > >medicines or insulin is commonly prescribed. Insulin level in blood
> > > > > > > > > >can be higher in blood due to insulin resistance, then what is the use
> > > > > > > > > >of furthur raising its level by medications?
> > > > > > > > >
> > > > > > > > > When the house gets too drafty, one should close the windows
> > > > > > > > > or improve the insulation. If that is not possible, put more
> > > > > > > > > fuel on the fire.
> > > > > > > > >
> > > > > > > > > Most biochemical activities can be pushed by overloading the
> > > > > > > > > amount of one of the reactants, just as if a door is poorly
> > > > > > > > > lubricated, pushing harder can make it work.
> > > > > > > > >
> > > > > > > >
> > > > > > > > Well written. Would concur :-)
> > > > > > > >
> > > > > > > >
> > > > > > > > Servant to the humblest person in the universe,
> > > > > > > >
> > > > > > > > Andrew
> > > > > > > >
> > > > > > > > --
> > > > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > > > Board-Certified Cardiologist
> > > > > > > > http://www.heartmdphd.com/
> > > > > > > >
> > > > > > > > **
> > > > > > > > Who is the humblest person in the universe?
> > > > > > > > http://makeashorterlink.com/?L26062048
> > > > > > > >
> > > > > > > > What is all this about?
> > > > > > > > http://makeashorterlink.com/?R20632B48
> > > > > > > >
> > > > > > > > Is this spam?
> > > > > > > > http://makeashorterlink.com/?N69721867
> > > > > > >
> > > > > > > Thanks,
> > > > > >
> > > > > > You are welcome.
> > > > > >
> > > > > > All praises go to my heavenly Father, Whom I love with all my heart,
> > > > > > soul, mind, and strength :-)
> > > > > >
> > > > > >
> > > > > > > but it seems to be common thought.
> > > > > >
> > > > > > Herman Rubin has God's gift of eloquence for the written word so that
> > > > > > thoughts are conveyed so clearly as to seem "common."
> > > > > >
> > > > > >
> > > > > > > How adding more insulin to
> > > > > > > already excess insulin can produce such effects bio-chemically.
> > > > > >
> > > > > > There are chemical reaction equations that would explain this.
> > > > > >
> > > > > > > It
> > > > > > > looks more logical that excess insulin & BG should cause alike more
> > > > > > > indigetion or unwillingness of taking these by target cells.
> > > > > >
> > > > > > Cells do not suffer from indigestion. When they become loaded with
> > > > > > excess glucose, they do start down-regulating the number of insulin
> > > > > > receptors on their surfaces.
> > > > > >
> > > > > > > Insulin
> > > > > > > being more complex,bigger molecule & may be toxic in excess(BG may not
> > > > > > > because a regular food & simpler molecule)should be the first
> > > > > > > canditate for resistance by target cells than glucose.
> > > > > >
> > > > > > Insulin (a polypeptide) does not enter the cells as glucose does.
> > > > > >
> > > > > > May God bless you today, dear Kumar whom I love, in Christ's holy name.
> > > > > >
> > > > > >
> > > > > > Servant to the humblest person in the universe,
> > > > > >
> > > > > > Andrew
> > > > > >
> > > > > > --
> > > > > > Dr. Andrew B. Chung, MD/PhD
> > > > > > Board-Certified Cardiologist
> > > > > > http://www.heartmdphd.com/
> > > > > >
> > > > > > **
> > > > > > Who is the humblest person in the universe?
> > > > > > http://makeashorterlink.com/?L26062048
> > > > > >
> > > > > > What is all this about?
> > > > > > http://makeashorterlink.com/?R20632B48
> > > > > >
> > > > > > Is this spam?
> > > > > > http://makeashorterlink.com/?N69721867
> > > > >
> > > > > "Cells do not suffer from indigestion. When they become loaded with
> > > > > excess glucose, they do start down-regulating the number of insulin
> > > > > receptors on their surfaces."
> > > > >
> > > > > What happens to these insulin receptors when cells become normar or
> > > > > deficient to glucose exposure?
> > > >
> > > > The opposite.
> > > >
> > > > > Can't this down-regulating of number of
> > > > > insulin receptors be due to excess insulin load instead of glucose?
> > > >
> > > > It can but isn't.
> > > >
> > > >
> > > > > Calcium channel blocker a medicine for hypertension causes increase in
> > > > > blood sugar level. Can we then think that,calcium can be related to
> > > > > insulin resistance?
> > > >
> > > > No. Insulin resistance would be suspected only when it can be
> > > > demonstrated that there are higher levels of blood glucose despite
> > > > higher levels of insulin.
> > > >
> > > > May God bless you on this Lord's day, dear Kumar whom I love, in
> > > > Christ's holy name.
> > > >
> > > > Servant to the humblest person in the universe,
> > > >
> > > > Andrew
> > > >
> > > > --
> > > > Dr. Andrew B. Chung, MD/PhD
> > > > Board-Certified Cardiologist
> > > > http://www.heartmdphd.com/
> > > >
> > > > **
> > > > Who is the humblest person in the universe?
> > > > http://makeashorterlink.com/?L26062048
> > > >
> > > > What is all this about?
> > > > http://makeashorterlink.com/?R20632B48
> > > >
> > > > Is this spam?
> > > > http://makeashorterlink.com/?N69721867
> > >
> > > thanks.
> >
> > You are welcome. All praises belong to my heavenly Father Whom I love
> > with all my being :-)
> >
> > > Both insulin & glucose are exposed in excess totarget cells
> > > in insulin resistance coditions.
> >
> > Not a true depiction. Exposure suggests that there insulin and glucose
> > are variables being manipulated by someone or something in an
> > unregulated fashion.
> >
> >
> > > How you can decide that it is BG not
> > > insulin which results dawn regulating of recepors?
> >
> > You do the experiments through research.
> >
> >
> > > Is is not correct that after some time all insulin resistant patients
> > > become non insulin resistant or type1?
> >
> > No. It is not correct. Type 2 diabetes remain type 2 even if they
> > start requiring insulin because of beta cell failure.
> >
> >
> > > How, when BG level remains
> > > always higher ev at later stages?
> >
> > Blood glucose level is a function of many things.
> >
> >
> > > How hyperglycemia is possible with excess dose of medicine or injected
> > > insulin in view of total glucose level in body(not in blood) remains
> > > same?
> >
> > Insulin resistance. Total body glucose is not invariant.
> >
> >
> >
> > Servant to the humblest person in the universe,
> >
> > Andrew
> >
> > --
> > Dr. Andrew B. Chung, MD/PhD
> > Board-Certified Cardiologist
> > http://www.heartmdphd.com/
> >
> > **
> > Who is the humblest person in the universe?
> > http://makeashorterlink.com/?L26062048
> >
> > What is all this about?
> > http://makeashorterlink.com/?R20632B48
> >
> > Is this spam?
> > http://makeashorterlink.com/?N69721867
>
> "No. It is not correct. Type 2 diabetes remain type 2 even if they
> start requiring insulin because of beta cell failure."
>
> Is there any stage in type2 patients with insulin resistance, when
> insulin resistance is no more?

When/if they become lean.

> I mean whether IR condition is life
> long or reduces as diabetes progress with the age or when beta cells
> are no more able to produce any insulin.
>
> "Insulin resistance. Total body glucose is not invariant."
>
> Do you mean IR can be a cause to hypoglycemea?

No.

> Whether hypoglycemea is
> experianced due to less BG or due to less/not going into cells?

Your question is not clear.
 
> Furthur, under Hormone receptor regulation as per below link, it looks
> hormones are responsible for receptors regulations. Why then insulin
> can't act as receptor's regulator?
> http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=endocrin.section.33

Symptomatic hypoglycemia keeps insulin levels from ever being
excessive enough to down-regulate its receptor.
 
> Best wishes.

Same for you.

Servant to the humblest person in the universe,

Andrew 

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/
**
Who is the humblest person in the universe?
http://makeashorterlink.com/?L26062048
What is all this about?
http://makeashorterlink.com/?R20632B48
Is this spam?
http://makeashorterlink.com/?N69721867

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