Re: CoQ10 and Coumadin was Re: Wonders of CO Q10
filipe_at_mercenary3.com
Date: 12/08/04
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Date: 8 Dec 2004 13:10:19 -0800
CoQ10 and its reaction with prescription drugs is touched on here:
http://www.justwebit.com/members/6584/coq10-side-effects.shtml
"Oral agents that lower blood sugar such as glyburide and
lipid-lowering drugs such as gemfibrozil and statins (lovastatin,
pravastatin, and simvastatin) limit the effectiveness of CoQ10. This
class of drugs cause a reduction in serum levels of CoQ10, resulting in
this limitation."
The National Cancer Institute also states:
"Certain lipid-lowering drugs, such as the "statins" (lovastatin,
pravastatin, and simvastatin) and gemfibrozil, as well as oral agents
that lower blood sugar, such as glyburide and tolazamide, cause a
decrease in serum levels of coenzyme Q10 and reduce the effects of
coenzyme Q10 supplementation. Beta-blockers (drugs that slow the heart
rate and lower blood pressure) can inhibit coenzyme Q10-dependent
enzyme reactions. The contractile force of the heart in patients with
high blood pressure can be increased by coenzyme Q10 administration.
Coenzyme Q10 can reduce the body's response to the anticoagulant drug
warfarin. Finally, coenzyme Q10 can decrease insulin requirements in
individuals with diabetes."
[References]
1. Pepping J: Coenzyme Q10. Am J Health Syst Pharm 56 (6): 519-21,
1999. [PUBMED Abstract]
2. Overvad K, Diamant B, Holm L, et al.: Coenzyme Q10 in health and
disease. Eur J Clin Nutr 53 (10): 764-70, 1999. [PUBMED Abstract]
3. Hodges S, Hertz N, Lockwood K, et al.: CoQ10: could it have a role
in cancer management? Biofactors 9 (2-4): 365-70, 1999. [PUBMED
Abstract]
4. Heller JH: Disease, the host defense, and Q-10. Perspect Biol Med 16
(2): 181-7, 1973 Winter. [PUBMED Abstract]
5. Baggio E, Gandini R, Plancher AC, et al.: Italian multicenter study
on the safety and efficacy of coenzyme Q10 as adjunctive therapy in
heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med
15 (Suppl): s287-94, 1994. [PUBMED Abstract]
6. Feigin A, Kieburtz K, Como P, et al.: Assessment of coenzyme Q10
tolerability in Huntington's disease. Mov Disord 11 (3): 321-3, 1996.
[PUBMED Abstract]
7. Kaikkonen J, Nyyssönen K, Tuomainen TP, et al.: Determinants of
plasma coenzyme Q10 in humans. FEBS Lett 443 (2): 163-6, 1999. [PUBMED
Abstract]
8. Thibault A, Samid D, Tompkins AC, et al.: Phase I study of
lovastatin, an inhibitor of the mevalonate pathway, in patients with
cancer. Clin Cancer Res 2 (3): 483-91, 1996. [PUBMED Abstract]
9. Coenzyme Q10. In: Jellin JM, Hitchens K, eds.: Natural Medicines
Comprehensive Database. Stockton, Calif: Therapeutic Research Faculty,
1999, pp 241-42.
(Make your own decisions about <a
href="http://www.nutritionalcenter.com">nutritional supplements</a>:
http://www.nutritionalcenter.com)
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