Re: Heart failure patients treated for diabetes with insulin have increase in mortality
From: William Wagner (No1SpamStill__B2wagner_at_snip.net)
Date: 01/01/05
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Date: Sat, 01 Jan 2005 07:58:39 -0500
1: J Hypertens. 1996 Feb;14(2):229-35.
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The relationship of blood pressure with glucose, insulin, heart rate,
free fatty acids and plasma cortisol levels according to degree of
obesity in middle-aged men.
Filipovsky J, Ducimetiere P, Eschwege E, Richard JL, Rosselin G, Claude
JR.
INSERM Unit 258, Paris, France.
OBJECTIVE: To investigate the relationships of blood pressure with
carbohydrate metabolism, sympathetic activity and cortisol at different
levels of body mass index in middle-aged men. METHODS: Cross-sectional
data concerning men studied in the Paris Prospective Study I were
analysed. The cohort included 6424 subjects aged 40-53 years at entry,
who were not being treated for hypertension or diabetes and had no overt
heart disease. The parameters analysed were glucose, insulin and free
fatty acids levels, all assessed during fasting by the subject and 2 h
after a 75 g glucose load, resting heart rate and morning plasma
cortisol levels. RESULTS: Subjects with systolic blood pressure > or =
160 mmHg had significantly higher glucose concentrations at any body
mass index level whereas the difference in insulin levels between the
subjects with and without high systolic blood pressure increased with
body mass index. Heart rate, free fatty acids level and cortisol level
were significantly higher in men with high systolic blood pressure.
However, these parameters showed significant decreasing trends with body
mass index. In normotensives, no such trends were observed. When
analysing data according to diastolic blood pressure, the limit being 95
mmHg, similar results were obtained for glucose and insulin levels, but
no trend in heart rate, free fatty acids level and cortisol level with
the body mass index level was statistically significant. CONCLUSIONS:
Mean glucose concentrations are higher in hypertensive men at all body
mass index levels, whereas relative hyperinsulinaemia is present only in
the more corpulent hypertensives. Heart rate, free fatty acids level and
morning plasma cortisol level are elevated in hypertensive subjects at
any body mass index level, but particularly in the lean ones with high
systolic blood pressure.
PMID: 8728301 [PubMed - indexed for MEDLINE]
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