Re: You can now verify positively if it is due to statin adverse effects Re: memory loss after CABG

From: Sharon Hope (shope_at_anet.net)
Date: 01/28/05


Date: Thu, 27 Jan 2005 21:04:24 -0800


"Don Kirkman" <donkirk@covad.net> wrote in message
news:62piv09mtfgq06srsgd86b3biqstl4g1ii@4ax.com...
> It seems to me I heard somewhere that Paul E. Lehmann wrote in article
> <10vhlmchg75dd91@corp.supernews.com>:
>
>>Don Kirkman wrote:
>
>>> Oversimplification probably ruins as many database projects as it does
>>> other human endeavors. Money, money, money, money.
>
>>Commerical off the shelf data base programs are available and some of them
>>are even free - consider the excellent data base programs that you can run
>>on Linux. A GUI front end for the database is NOT that difficult to
>>design
>>either.
>
> Do you or Sharon know of an off the shelf program that can handle all
> medical records involving statin and/or mental acuity measure for any
> state, much less for the entire US or for, say, a joint system for the
> US and Canada? IMO anything on less than the state level will be too
> fragmented to be worthwhile, and certainly a nationwide system would be
> much more useful.
>
>>Perhaps you are thinking of the old days when data base programs were all
>>specially designed - the government had / has tons of these. For years
>>many agencies thought they could do a better job than commerical off the
>>shelf products. Those days are gone. I worked for the National Weather
>>Service that finally woke up and ditched their self written data base
>>program and switched to Informix.
>
> No, I'm definitely thinking of the future days Sharon seems to be asking
> for, when millions of data items will be processed daily, and need to be
> organized and preserved for instant retrieval by doctors, health care
> researchers, government planners, and perhaps even by individual
> patients. Even a company like Oracle would probably have to tweak one
> or more of their products to make it possible.
>

The size of a database where "millions of data items will be processed
daily" is not a major challenge. Think about the difference between these
reports and, for example, the data downlinked from a typical earth observing
satellite with several instruments and a camera on board. Think what it
takes, for example, to catch, catalog and store the constant stream of
science data coming down that produces these kinds of images, which dwarf
mere text records, or even text and images (e.g., Xrays, MRIs, etc.):

In the News:
http://earthobservatory.nasa.gov/Newsroom/

* Latest Images:
  Prado Dam
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16801

  Record Blizzard Buries U.S. Northeast
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16800

  Tsunami Damage, Northwestern Sumatra (Indonesia)
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16799

  Breaking Tsunami Waves along India&#8217;s Eastern Coast
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16798

  Crater Lake National Park
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16797

  Snow on the Summits of Hawaii
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16796

  Satellites Map Tsunami Wave Height
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16795

  Floods Along the Ohio River
  http://earthobservatory.nasa.gov/Newsroom/NewImages/images.php3?img_id=16794

Then, just for fun, take a look at
http://www.sti.nasa.gov/tto/spinselect.html to see what kind of software is
available for 'spinoff' from NASA alone:

            The Spinoff database will help you find products/services that
incorporate NASA technology in such areas as health and medicine,
environment, public safety, consumer/home/recreation, transportation,
computer technology and industrial productivity. You can find the date of
the publication, page number, the center responsible for the technology, and
the original NASA program in which the technology was developed if
applicable.

            The NASA Spinoff Database is on a WAIS server using the WAIS
search engine. Access is available through several popular clients such as
NCSA Mosaic and Netscape using a WAIS gateway and through Gopher. Searching
can be done as natural language, literal strings, and/or Boolean queries.
Fielded searches are for clients accessing through the WAIS gateway. Further
details about searching are explained in the Frequently Asked Questions
(FAQ), How Do I Search the NASA Spinoff Database?

            Do your own searches. You would be amazed what is there,
available for practical use. example:

      http://www.sti.nasa.gov/cgi-bin/waisgate?WAISdocID=88742311190+3+0+0&WAISaction=retrieve&WAISlogFile=/home3/wais/waislog

View from Above w/out Leaving the Ground
  Publication
  SPINOFF 2004

  Page
  72

  Center
  Goddard Space Flight Center

  Origin
  NASA Regional Applications Center

  Manufacturer
  High Performance Database Research Center

  11200 SW 8th Street Miami, FL 33199

  (305) 348-6262

  Tech Terms
  remote sensing, imagery, geospatial, database, real estate

  Abstract
  In 1996, Goddard Space Flight Center agreed to establish a Regional
Applications Center at Florida International University. TerraFly, one of
the projects stemming from the collaborative effort, makes it possible for
users to "fly over" vast areas of land using only an ordinary Web browser.
TerraFly does not require the installation or downloading of any specialized
geographic information systems software, unlike many other data systems. The
Internet-based technology was developed to make geospatial data more
accessible to the average user. It is currently one of the largest publicly
accessible image repositories on the Web, hosting more than 30 terabytes of
data, including land, urban, and coastal imagery collected by satellites,
aerial photography, and other means of remote sensing. Whether it is sheer
personal interest to navigate the American skies or map-planning for land
development or zoning, TerraFly was designed to be a simple and convenient
system for users of all levels (by simply typing in a street address or a
zip code, one can obtain an overhead view of the desired location). In
flying over the imagery, the user can see various overlays, including road
names, public buildings, and landmarks. With varying resolutions, a user can
get close enough to see cars parked on the streets, or far enough to view
the land as it actually looks from high above the clouds.

>>The technology issue is NOT an issue. Getting laws passed requiring
>>health
>>care professional to enter the data in the data base is the problem. But,
>>hey, they are now REQUIRED to report sexually transmitted disease.
>>Reporting drug side effects should not be that big a problem - Unless of
>>course, pharmas fought such legislation tooth and nail.
>
> The unspoken issue is what happens to the reports. Unless they can be
> consolidated into a corpus suitable for research, and unless there are
> researchers with the time and resources to use the information, it seems
> likely to create one more pile of government reports shoved into a file
> cabinet in a corner.
>
> Did you or Sharon happen to notice that what I'm pointing out is
> precisely the political and economic difficulties, not the technological
> ones?

That is where I came in - it is a management and a policy problem. Funding,
yes, but it is the decisionmaking, management and policy that is lacking.
The technology is readily available and can be had for little or no money.

Doctors and other users input the data via web - system administration and
database administration and website maintenance are readily available and
affordable talents.

The Safety Watchdog Agency they are postulating as a counterpoint to the FDA
would be the recipient of the reports (and, hopefully, the NIH, and the
public) Trend analysis is fairly straightforward.

What would be left to do is back to a Management and Policy issue: enforce
the mandatory research into treatment and prevention of the adverse effects.
In other words, get the Rx industry to clean up its own messes.

There might be another side effect of such a program: It might provide a
financial incentive to the pharm industry to start to produce medications
that actually cure problems, rather than treat forever.

Currently, for example, statins are prescribed "for life" - treatment, not
cure. If the likelihood of having costs incurred as the life-long exposure
produced more and more adverse effects that the company was then obligated
to treat to recovery and screen to prevent others from becoming affected, it
might, just might make it a much more lucrative venture to focus on
treatments that cure after a shorter term of treatment (which would narrow
the window of opportunity for those expensive adverse effects to appear).

What a concept!

> --
> Don
> "I do not feel obliged to believe that the same God who has endowed
> us with senses, reason, and intellect has intended us to forgo their
> use. --Galileo Galilei

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