Re: Grapefruit juice and statins
From: Peabody (waybackKILLSPAM44_at_yahoo.com)
Date: 02/04/05
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Date: Fri, 04 Feb 2005 17:05:59 -0600
jorge shmuck says...
> All of the reports that I've read about not drinking
> grapefruit juice while taking statins fail to mention
> certain questions: Are they saying to not wash the
> pill down with a gulp of juice, or to avoid grapefruit
> juice completely if you're taking statins? What about
> eating grapefruit, in general? .... and
> grapefruit-flavored citrus sodas and drinks? (if I'm
> not mistaken, the official name in pharmacalogy and
> mixology terms for vodka-and-grapefruit is a "Greyhound"
It depends on which statin you are taking. Atorvastatin,
simvastatin, and lorvastatin are metabolized (removed from
the body) by something called CYP 3A4, which is inhibited by
grapefruit juice, and by a number of other prescription
drugs, including even some common blood pressure drugs such
as verapamil and diltiazem. So if you are taking one of
those statins, you probably should stay away from grapefruit
and grapefruit juice entirely so that you don't overdose.
However, fluvastatin and pravastatin are metabolized by
other mechanisms, and there should be no interaction between
grapefruit and those statins. However, there could still be
an interaction between grapefruit and some other drug you
are taking, so you need to clear it with your doctor if you
plan to consume grapefruit.
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