Re: drugs that deplete coq10
From: Alan S (loralweightandcarbs_at_optusnet.com.au)
Date: 02/13/05
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Date: Sun, 13 Feb 2005 19:43:53 +1100
On Sat, 12 Feb 2005 23:03:38 -0600, "William C Biggs MD"
<iiweulojrtom@spammotel.com> wrote:
|Charly,
|
|Co-Q is readily available OTC. Even Sam's Warehouse Club carries it now.
|
|If a patient on a statin complains of any myalgia or muscle weakness, I
|usually have them try 150mg a day.
|
|Depending on the severity of the complaints, I might check a CK level to
|look for muscle inflammation. If the CK is high, I will stop the statin.
|Statins can cause myalgias or muscle weakness even with a normal CK level.
|In that scenario Co-Q is often very beneficial, and can relieve the muscle
|complaints.
|
|I haven't heard of any adverse effects of Co-Q , other than some people have
|found their BG was lower while taking it.
|
|BTW, one of my attendings from medical school , Michael Brown, and Merck
|patented the concept of adding Co-Q to a statin back in 1990.
|
|Dr Brown shared the Nobel prize in Medicine with Joseph Goldstein for their
|discovery of the statin drugs. Look at patent 4,933,165 at www.uspto.gov .
|
|IMHO, the incidence of myalgia while taking statins is WAY under-reported.
|That's why I wrote the letter published in the Wall Street Journal
|criticizing Pfizer for its plans to only market torcetrapib in combination
|with atorvastatin (Lipitor). Those persons with muscle problems on statins
|will not be able to get torcetrapib.
|
|This scenario reminds me of the mid 80's when patients were telling their
|doctors that meds like Prozac reduced their libido, and the drug companies
|claimed it was no different than placebo.
|
|
|The concept of a combination Co-Q / statin drug makes a lot of sense to me.
|It makes a lot more sense than "Caduet" which is combines Norvasc and
|Lipitor, or the 2002 winner of "Stupidest Drug Marketing Idea of the Year
|Award".... Pravagard , which was simply a package with Pravachol and an
|aspirin tablet. Not in the same pill mind you, it was two separate tablets.
|
|Cheers,
|
|William C Biggs, MD
|
Hi Doctor Biggs
I've just changed from lipitor20 to pravachol20 to see if I can stop
my occasional night leg cramps. I found this answer of yours
interesting, so I went searching a little to see if I could find some
dietary sources to meet the need, rather than supplements.
In that process I came across this page,
http://www.catie.ca/tu.nsf/0/9C59AE93CAEE073285256A8C006A007A?opendocument&language=english
or http://tinyurl.com/448q3
on a site mainly related to AIDS/HIV. They reinforce what you said,
but note:
"Available forms and usage
The body can make Q10 using the amino-acid tyrosine, B-complex
vitamins and vitamin C. Foods that are good sources of Q10 are usually
cholesterol-rich and include the following:
pork
beef
chicken
herring
Bear in mind that it is almost impossible to obtain a high level ? 200
mg ? of Q10 in one day from food sources alone."
Are you aware of any other dietary sources that would help in meeting
the daily need without exceeding other limits like saturated fats or
cholesterol?
Cheers Alan, T2, Australia.
-- Everything in Moderation - Except Laughter.
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