Re: British government links statin drugs to 92 deaths
From: Sharon Hope (shope_at_anet.net)
Date: 03/07/05
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Date: Sun, 6 Mar 2005 17:25:18 -0800
"Sharon Hope" <shope@anet.net> wrote in message
news:VbSdnakysaIzOrbfRVn-tA@comcast.com...
> http://www.timesonline.co.uk/article/0,,2087-1512613,00.html
>
> Last year a study of almost 150,000 people in Austria found that those
> with lowered cholesterol were more likely to die of cancer.
>
As posted in another thread, the study that they reference seems to be:
"in women from the age of 50 onward only, low cholesterol was significantly
associated with all-cause mortality, showing significant associations with
death through cancer, liver diseases, and mental diseases."
The abstract:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15006277
Why Eve is not Adam: prospective follow-up in 149650 women and men of
cholesterol and other risk factors related to cardiovascular and all-cause
mortality.
Ulmer H, Kelleher C, Diem G, Concin H.
J Womens Health (Larchmt). 2004 Jan-Feb;13(1):41-53.
Institute of Biostatistics and Documentation, Leopold Franzens University of
Innsbruck, Innsbruck, Austria. Hanno.Ulmer@uibk.ac.at
PURPOSE: To assess the impact of sex-specific patterns in cholesterol levels
on all-cause and cardiovascular mortality in the Vorarlberg Health
Monitoring and Promotion Programme (VHM&PP). METHODS : In this study, 67413
men and 82237 women (aged 20-95 years) underwent 454448 standardized
examinations, which included measures of blood pressure, height, weight, and
fasting samples for cholesterol, triglycerides, gamma-glutamyl transferase
(GGT), and glucose in the 15-year period 1985-1999. Relations between these
variables and risk of death were analyzed using two approaches of
multivariate analyses (Cox proportional hazard and GEE models). RESULTS:
Patterns of cholesterol levels showed marked differences between men and
women in relation to age and cause of death. The role of high cholesterol in
predicting death from coronary heart disease could be confirmed in men of
all ages and in women under the age of 50. In men, across the entire age
range, although of borderline significance under the age of 50, and in women
from the age of 50 onward only, low cholesterol was significantly associated
with all-cause mortality, showing significant associations with death
through cancer, liver diseases, and mental diseases. Triglycerides > 200
mg/dl had an effect in women 65 years and older but not in men. CONCLUSIONS:
This large-scale population-based study clearly demonstrates the contrasting
patterns of cholesterol level in relation to risk, particularly among those
less well studied previously, that is, women of all ages and younger people
of both sexes. For the first time, we demonstrate that the low cholesterol
effect occurs even among younger respondents, contradicting the previous
assessments among cohorts of older people that this is a proxy or marker for
frailty occurring with age.
PMID: 15006277 [PubMed - indexed for MEDLINE]
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