Re: Low Magnesium Linked to Epidemic of Heart Disease?

From: Robert (RobertJ_at_hotmail.com)
Date: 03/13/05 

Date: Sun, 13 Mar 2005 01:31:19 -0800

"LadyLollipop" <LadyLollipop@insightbb.com> wrote in message
news:P%RYd.124093$tl3.79531@attbi_s02...
>
> "Robert" <RobertJ@hotmail.com> wrote in message
> news:v9adnYcg1Mq_fK7fRVn-2Q@got.net...
> >
> > "LadyLollipop" <LadyLollipop@insightbb.com> wrote in >
> >
> > Starting with a woman suffering from low levels of magnesium in her
blood,
> >> researchers found several family members with the same problem. They
> > located
> >> a previously unknown genetic mutation that linked family
> >
> > Serum or blood magnesium levels have never been the accepted criteria in
> > establishing tissue storage magnesium levels.
> > Magnesium like calcium is transported by binding proteins and those
> > binding
> > proteins may fluctuate and thus fluctuate the blood total calcium and
> > magnesium levels unrelated to tissue calcium or magnesium levels.
Ionized
> > magnesium levels are closer to tissue levels but still disparate in
> > clinical
> > situations.
>
> High blood pressure and cholesterol are very common problems, affecting a
> quarter of the adult population, and their cause has been unknown, Richard
> P. Lifton, lead researcher in the study, said in a telephone interview.
His

In other words my research is valuable to mankind and I must have more money
for my research. The way I do this is by tying in all of mans ills and most
common conditions and placing loose connections to my research. It helps me
get the mainstream press by exaggerating all my findings.

> findings were published online Thursday by the journal Science.
>
> Multiple illnesses
> Lifton, of the Howard Hughes Medical Institute, noted that high
cholesterol
> and blood pressure often occur together, and the newly found mutation
> results in some people in this family with multiple illnesses, including
> those.

What happened to finding the gene for diabetes? Or for obesity?
For heart disease?

>
> Since not everyone with hypertension or high cholesterol has the mutation,
> that raises the question of whether some other problem with the
> mitochondria, such as loss of function with aging, is also a factor in
those
> diseases, he said.
So now we get to mitochondria of course. Mitochondrial DNA. Oxidative damage
to mitochondria over time results in Alzeihmers as well. Lets throw that in
also.

> "Epidemiological studies over the last twenty years have shown that
> hypertension, high cholesterol, high triglycerides, low magnesium,
diabetes,
> insulin resistance and obesity tend to cluster with one another, but not
in
> a simple way," said Lifton, who works at Yale University.

Lol. Yeah, not in a simple way. Give me a why out if I am wrong but in the
meantime please donate to my research. But if I am wrong then it was because
it was not in a simple way.

>
> "Not everybody who has any one of these traits has all of the others. The
> pattern of inheritance is complicated, and there hasn't been a clear
> understanding of what's driving this relationship," he said.

Then why bring it up. Because he is simply speculating.
>
> Mitochondrial defects may link diseases

May link disease or it may not link diseases. It surely is linked in his
research. Donate to his research so he can link it all or not.

> The new report may indicate that mitochondrial function is what ties these
> illnesses together.

How can a new report do that. What report? Try doing some controlled
experiments instead of simply speculating.

>
> Dr. Douglas S. Kerr said researchers have known that diabetes can be
> associated with mitochondrial defects in families, and this study brings
> together two other illnesses - high blood pressure and cholesterol - that,
> when combined with diabetes, are known as metabolic syndrome.

A genius in the making. To think that genetics plays a role in disease is
astounding. To say they have the answers is laughable.

>
> The finding "is a piece of the puzzle that points to a better
understanding
> of the underlying mechanism. You have to collect many pieces of the
puzzle,
> but this is an important one," said Kerr, director of the Center for
> Inherited Disorders of Energy Metabolism at Case Western Reserve
University
> in Cleveland.

That's where you need to send the check to. What is that address again?

>
> The next goal, said Lifton, is to discover how mitochondrial defects cause
> illnesses.

The next goal!!!!!!!!!!!!!!
OMG. As if the first was already established. Talk about hype.
It's like quick, snap the ball before they have replay.

> It could be loss of energy, he said, since the mitochondria produce the
> body's
> energy, or, with age, the mitochondria may stop working properly and begin
> producing toxins.
Oh no, not very original. Toxins? Free radicals.
Or maybe not. Whether they are or are not is not important. What's more
important is that he be allowed a paycheck and have him publish.

>
> David Samuels, a professor at the Virginia Bioinformatics Institute at
> Virginia Tech, said that while the newly found mutation may be rare, "Our
> experience has been that if one mitochondrial mutation causes a disease,
> then other (mitochondrial DNA) mutations may also cause the same disease
...
> This gives us reason to look for these metabolic diseases in families with
> other mtDNA mutations," said Samuels, who was not part of the research
team.

They are all mitochondrial mutations therefore.
All diseases are mitochondrial mutations with point mutations of unkown
origin at present. If you can't get the data to come out the way it is
supposed to then tell them that is isn't that simply or that we don't know
all the point mutations that can cause disease. Need a way out.

> "Other things can cause these diseases as well, but this mitochondrial DNA
> mutation is definitely one cause," he said.

He is slipping as now you have competing resources. You go from speculation
to " definitely one cause".

>
> New targets for treatment
> Philip A. Wood, director of the genomics division at the University of
> Alabama at Birmingham, said that while "this particular mitochondrial DNA
> mutation is likely rare and possibly limited to this large family, what it
> reveals is important."
>
> "That is, this is a new mechanism involving mitochondrial dysfunction that
> may help explain parts of disease processes that affect a large number of
> people, but due to different underlying causes of mitochondrial
dysfunction
> such as aging," Wood said.
He goes from a very rare single family mutation to explaining large numbers
of disease individuals to age related dyfunction.
He forgot to mention cancer. Remember cancer was to be wipped out by cancer
research years ago.
>
> He added that "rare genetic variants, like this one, reveal new targets
not
> only for new drug development, but also may provide new approaches for
> diagnosis using an underlying cause, in this case a mitochondrial DNA
> mutation."
How are you going to diagnose it when it is only present in one family. LOL.
The whole point being that there are unknown mutations which are by
definition unkown.
OK lets say there are 500 mutations that can cause metabolic syndrome. Are
you going to do 500 tests for DNA mutations by PCR? Or are you going to do a
glucose, lipid panel and check for blood pressure.
More hype.

>
> The research was funded by the National Institutes of Health, the Howard
> Hughes Medical Institute and the American Heart Association.
>

To the exclusion of funds for cancer, HIV research, and safe guards against
drug manufacturer safety studies.

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