Re: FDA, User Fees, Adverse Effects, and Safety

From: William Wagner (No1SpamStill__B2wagner_at_snip.net)
Date: 03/27/05 

Date: Sun, 27 Mar 2005 13:27:38 -0500

In article <1111946407.841023.11640@l41g2000cwc.googlegroups.com>,
 "zee" <outrider@despammed.com> wrote:

> Jeff wrote:
> > "zee" <outrider@despammed.com> wrote in message
> > news:1111870262.277803.95930@l41g2000cwc.googlegroups.com...
> > >
> > > Jeff wrote:
> > >> "zee" <outrider@despammed.com> wrote in message
> > >> news:1111866431.096915.217960@z14g2000cwz.googlegroups.com...
> > >> > It is not unreasonable to think that a Prozac-altered physical
> > > (cardio)
> > >> > chemistry could be part of a chaotic mental state. Whether or
> not a
> > >> > prolonged QT (or anything) would "cause" suicide is a moot
> point.
> > >>
> > >> I disagree. Cardiac chemistry is below the neck; the mental state
> is
> > > above
> > >> the neck.
> > >>
> > >> You're reaching a bit too far.
> > >>
> > >> > Zee
> > >> >
> > >
> > >
> > >
> > > Cardiovascular includes vascular disease. No fire wall between the
> body
> > > and brain. Just ask someone suffering from diabetes, or AFIB.
> >
> > Actually, there is. It is called the "Blood Brain Barrier."
> >
> > Besides, the funtioning of the brain is independent of the electrical
>
> > rhythms of the heart.
> >
> > Jeff
>
>
>
> "...the functioning of the brain is independent of the electrical
> rhythms of the heart."
>
> Tell that to this person.
>
> Premature ventricular contractions and paxil:
> http://groups-beta.google.com/group/sci.med.cardiology/msg/c56564404212c073

Here is an interesting article on Brain Body . Still can't find
article I mentioned earlier but Maryland
http://www.marylandresearch.umd.edu/
may be the player.

Enjoy

Bill
........................................................................

Exercise: Good for the Body, Good for the Brain

http://www.infoaging.org/feat28.html
By Laurel Tielis,
 Infoaging Correspondent

Everywhere we turn, we hear information about the benefits of exercise
in building stronger bones and muscles and reducing the incidence of
illnesses from diabetes to heart disease. A growing body of research
however, is demonstrating that exercise is not just good for your body,
it's good for your brain.

Physical activity can be beneficial to stroke victims, people suffering
from dementia, even those who are the clinically depressed. This was a
key finding from a panel of doctors and researchers who spoke recently
in New York City at an American Federation for Aging Research seminar
entitled "Staying on Top of Your Game."

 Exercise and stroke
Exercise can play a transformative role in the way the brain responds to
stroke. It can make the difference between being in a wheelchair to
navigating with a cane, according to Dr. Andrew Paul Goldberg, head of
the Division of Gerontology in the Department of Medicine at the
University of Maryland School of Medicine. In working with Richard
Macko, MD. Associate Professor of Neurology and Jill Whitall, PhD, PT,
Professor in the Department of Physical Therapy, Dr. Goldberg says they
have found that through repetitive exercise, the healthy part of the
brain can be trained to take over the work of the damaged part.

"The interesting thing we find," said Dr. Goldberg at the seminar, "is
that someone who has a stroke has damage to one side of the brain; if
the stroke is on the left, you lose function on the right." To help the
undamaged side of the brain take over some of the functions of the
damaged side, patients are given "reciprocal repetitive training." In
the past, standard practice had been to take the weakened arm or leg and
have it lift weights working against resistance. What Dr. Goldberg and
his team have done is have the good side work first and follow it with
the bad side in a repetitive rhythm. Think of walking on a treadmill;
one leg automatically follows the other.

Results are seen first in the upper body; walking takes longer. But
according to Dr. Goldberg, after six weeks of training in the upper body
and six months in the lower body, "(Patients) get right into rhythm.
It's like poetry in motion; it's amazing."

What's also amazing is that as long as five to seven years after a
stroke, patients can improve dramatically. Dr. Goldberg said, "There is
the potential to take a very disabled population and get them totally
back to normal function. That would allow many to leave nursing homes."

Exercise and dementia
 Beyond stroke, exercise can also have positive benefits for people with
other so-called "brain diseases." "There is a growing body of literature
that indicates physical activity is associated with a decreased
incidence of dementia and Alzheimer's disease," according to Dr. William
Evans, director of the Nutrition, Metabolism and Exercise Laboratory in
the Donald Reynolds Department of Geriatrics at the University of
Arkansas.

"We don't hypothesize that exercise will make people less demented," he
said, but a current project he is involved with is examining whether
people with dementia in nursing homes sleep better and have a better
quality of life if they exercise. "They sleep during the day, and
because of that, do not sleep well at night," he explains, "basically
because there is nothing to occupy their minds. The hypothesis is that
making them stronger and more active during the day will improve their
sleep patterns at night."

Exercise and Depression
 Numerous studies looking at the effects of exercise on depression have
found that physical activity can increase self-esteem, decrease anxiety
and improve mood and sleep patterns.

In a Harvard study, 32 depressed people aged 60 and over were randomly
assigned to those who followed resistance training and those in a
control group. Those who received the training made noticeable gains in
vitality, mood and the ability to function in social settings. Their
strength was seen to increase by a significant 33 per cent.

A similar study in Sweden focused on 40 seniors with an average age of
66. At the end of three months of working out three times a week, the
exercise group had a significantly better rate of ability to perform
complex tasks than the control group.

Dr. Thomas Prohaska, a professor in the department of the Division of
Community Health Sciences at the University of Illinois at Chicago
School of Public Health and a co-director of the University of Illinois
Center for Research on Health and Aging, is finishing a review of the
effect of exercise in older adults. Funded by the Centers for Disease
Control, Dr. Prohaska said its purpose is to see how physical activity
impacts on all aspects of daily life. Six different content areas are
being followed: quality of life; depression; self-efficacy; cognitive
function; anxiety and mood.

>From the studies he's been following he noted, "Aerobics and strength
exercise both have some effect on mental health in older adults." He
also said, "We don't have a lot of research on anxiety and depression,
but looking at the studies we have, more than half were significant and
show a need for long-term studies."

 

Selected References:

Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME,
 Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ. Exercise training and
nutritional supplementation for physical frailty in very elderly people.
N Engl J Med. 1994 Jun 23;330(25):1769-75. PMID: 8190152

Macko RF, Smith GV, Dobrovolny CL, Sorkin JD, Goldberg AP, Silver KH.
Treadmill training improves fitness reserve in chronic stroke patients.
Arch Phys Med Rehabil. 2001 Jul;82(7):879-84. PMID: 11441372

 Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of
cardiorespiratory fitness and cognitive function in healthy older
adults. J Am Geriatr Soc. 2003 Apr. 51(4):459-65. PMID: 12657064

Colcombe SJ, Erickson KI, Raz N, Webb AG, Cohen NJ, McAuley E, Kramer
AF.
 Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A
Biol Sci Med Sci. 2003 Feb;58(2):176-80. PMID: 12586857

 

Reviewed and Published: November 24, 2003 

-- 
Zone 5 S Jersey USA Shade 
"oeuf tôt pique " Lover
"Physics is like sex: sure, it may give some practical results, but
that's not why we do it."   -- Richard P. Feynman (Nobel Prize, Physics)

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