Re: Niacin heptatoxicity
- From: "hawki63" <hawki63@xxxxxxxxxxxxx>
- Date: Mon, 04 Apr 2005 17:16:23 GMT
good for you Gary
my hubby could NEVER get past the flushing effect...he takes an aspirin EVEN
with the time released type!!!
he is up to 2000 mg now....
good luck to you..
"GaryG" <sorrynoemail@xxxxxxxxxxx> wrote in message
news:c054e.2290$KL5.1116@xxxxxxxxxxx
> "hawki63" <hawki63@xxxxxxxxxxxxx> wrote in message
> news:FZ14e.15087$zl.8104@xxxxxxxxxxxxxxxxxxxxxxxxxxxxx
> > exactly what is says
> >
> > that "sustained release" niacin...as opposed to immediate release
> > niacin....can adversely affect the liver
> >
> > unfortunately....many if not most folks cannot tolerate the immediate
> > release...due to the flushing except..
>
> FWIW, you can build up a tolerance to the flushing effect, but it requires
> that you raise the dosage slowly over several months, and take the niacin
> every day without fail. Taking aspirin a half hour beforehand, and taking
> your initial doses just before going to sleep (so you're asleep when the
> flush hits), also helps.
>
> I've been taking 3000 mg / day of standard niacin for the last 4 or 5
years
> (1000 mg in the morning, and 2000 mg before bed in the evening). As long
as
> I take it religiously, the flushing does not occur.
>
> But, if you stop taking it for even a few days, you'll lose your tolerance
> to the flushing effect. I found this out the hard way a few years ago.
I'd
> run out of niacin for about a week before I could get resupplied, and when
I
> took my standard evening dosage, I flushed badly, and turned bright red.
I
> had an important business meeting the next morning, and was very glad I
> didn't discover the problem then :-). Within a few days, the problem went
> away as I reacquired my tolerance.
>
> GG
>
>
> > your doc should be checking your liver function on a regular basis if
you
> > are taking sustained release..
> >
> >
> > "Robin H" <robinh@xxxxxxxx> wrote in message
> > news:fd14e.889681$Xk.464441@xxxxxxxxxxx
> > > Can anybody explain to me what this means. I read it in J Fam Pract.
> 2005
> > > Mar;54(3):265-8.
> > >
> > > Because [sustained-release/long-acting] niacin has an active
metabolite
> > > (nicotinamide), hepatotoxicity is more likely to occur with the
> > > [sustained-release/long-acting] formulation than with
> [immediate-release]
> > > niacin.
> > >
> > > The article references Clin Liver Dis. 2003 May;7(2):415-33 but I dont
> > have
> > > this journal in my library.
> > >
> > > Thanks
> > >
> > > Robin
> > >
> > >
> >
> >
>
>
.
- References:
- Niacin heptatoxicity
- From: Robin H
- Re: Niacin heptatoxicity
- From: hawki63
- Re: Niacin heptatoxicity
- From: GaryG
- Niacin heptatoxicity
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