Re: Niacin heptatoxicity

I can read, you know. I wish to understand why one is more hepatotoxic than
the other and what nicotinamide has to do with it.

Robin

"hawki63" <hawki63@xxxxxxxxxxxxx> wrote in message
news:FZ14e.15087$zl.8104@xxxxxxxxxxxxxxxxxxxxxxxxxxxxx
> exactly what is says
>
> that "sustained release" niacin...as opposed to immediate release
> niacin....can adversely affect the liver
>
> unfortunately....many if not most folks cannot tolerate the immediate
> release...due to the flushing except..
>
> your doc should be checking your liver function on a regular basis if you
> are taking sustained release..
>
>
> "Robin H" <robinh@xxxxxxxx> wrote in message
> news:fd14e.889681$Xk.464441@xxxxxxxxxxx
>> Can anybody explain to me what this means. I read it in J Fam Pract. 2005
>> Mar;54(3):265-8.
>>
>> Because [sustained-release/long-acting] niacin has an active metabolite
>> (nicotinamide), hepatotoxicity is more likely to occur with the
>> [sustained-release/long-acting] formulation than with [immediate-release]
>> niacin.
>>
>> The article references Clin Liver Dis. 2003 May;7(2):415-33 but I dont
> have
>> this journal in my library.
>>
>> Thanks
>>
>> Robin
>>
>>
>
>


.

Relevant Pages

  • Re: Niacin heptatoxicity
    ... > the other and what nicotinamide has to do with it. ... >> unfortunately....many if not most folks cannot tolerate the immediate ... >> your doc should be checking your liver function on a regular basis if ... >>> Robin ...
    (sci.med.cardiology)
  • Niacin heptatoxicity
    ... I read it in J Fam Pract. ... (nicotinamide), hepatotoxicity is more likely to occur with the ... niacin. ...
    (sci.med.cardiology)