Re: Snake Oil Cure what ails ya

sorry...you must have misunderstood my intent..

YOUR sentence read "I am constantly amazed that medical folks design a drug
for ONE symptom,,,than after a large population try it "claim" it is good
for something else...

precisely describes serendipity.... by your own definition,,serendipity is
defined as "accidentality"...

in the beta blocker example I used....beta blockers were designed for
cardiac symptoms...and tested for such...in the clinical
trials..voila...headache folks (like me BTW) noticed a distinct improvment
in headache frequency and intensity...

thus those us taking betas for cardiac reasons BECAME the petri dishes!!!

it worked for an indication that it was not designed for..in my case..I take
betas for palpitations...so in essence I can Kill two stones with one
bird(my brother's favorite misonmer)

I cannot understand why this is a problem...

during clinical trials..and we are talking 3 decades or so ago....beta
blockers showed improvement in headaches EVEN for those not helped by its
cardiac "intended" properties..

should pharma gone back to the drawing board and disregard the facts that
betas helped headaches??

not in my book...firstly...once a drug is FDA approved...it can be used
"offlabel" for any purpose that a prescriber feels it might help...betas for
many years ARE FDA approved for headache prevention...and that indication is
listed in the PDR


"William Wagner" <No1SpamStill__B2wagner@xxxxxxxx> wrote in message
news:No1SpamStill__B2wagner-C33FBE.16551310042005@xxxxxxxxxxxxxxxxxxx
> In article
> <No1SpamStill__B2wagner-891953.16342910042005@xxxxxxxxxxxxxxxx>,
> William Wagner <No1SpamStill__B2wagner@xxxxxxxx> wrote:
>
> > In article <jpf6e.522$dT4.4@xxxxxxxxxxxxxxxxxxxxxxxxxx>,
> > "hawki63" <hawki63@xxxxxxxxxxxxx> wrote:
> >
> > > this is called "serendipity"..
> > >
> > > ie when studying one drug for its intended purpose...the study
participants
> > > report that OTHER problems etc have improved...
> > >
> > > this happened many years ago with beta blockers...such as
Inderal...used for
> > > certain cardiac indications..
> > >
> > > voila..many many study participants reported a lessening or
elimination of
> > > their headaches...
> > >
> > > voila..beta blockers became on of the first line of "prevention" for
> > > migraine headache prophylasis...
> > >
> > > actually I find this not too surprising...as Jeff says...how can a
drug be
> > > tested for EVERY disease?? it can't..
> > >
> > > so when study participants ...who are followed closely...begin to
report
> > > similar "other" organ problem relief...what is wrong with THEN going
on to
> > > study such a drug for THAT indication??
> > >
> > >
> > > actually this happens all the time...with drugs in every
> > > classification...some drugs do NOT pan out to be effective for its
intended
> > > target...but DO prove another use...
> > >
> > > also...simply eliminating ANY med with adverse effects to some...would
> > > virtually eliminate all drugs...
> > >
> > > careful monitoring is obviously indicated...
> > >
> > >
> > > "William Wagner" <No1SpamStill__B2wagner@xxxxxxxx> wrote in message
> > > news:No1SpamStill__B2wagner-8AB809.19330208042005@xxxxxxxxxxxxxxxxxxx
> > > > I¹m constantly amazed that medical folks design a drug for one
> > > > symptom then after large populations try it claim it is good for
> > > > something else. REAL SCIENCE
> > > >
> > > > http://www.msneighborhood.com/content/in_the_news/archive_2221.aspx
> > > >
> > > > More at the above site.
> > > > Brevity below
> > > > ................................
> > > >
> > > > Statin Medication to be Tested Against MS
> > > >
> > > >
> > > > by John C. Martin
> > > > Article Date: 04-08-05
> > > >
> > > > Armed with promising evidence of the potential of certain
> > > > anti-cholesterol medications known as statins in the treatment of
> > > > multiple sclerosis (MS), medical experts are launching a large
clinical
> > > > trial to further test the safety and efficacy of these drugs.
> > > >
> > > > Investigators at more than a dozen medical institutions are
currently
> > > > enrolling patients for this Phase 2 trial, which is planned to
include
> > > > 152 people at high risk for developing the illness. The drug being
> > > > tested is atorvastatin (uh-TOR-vuh-stat-ihn), marketed as Lipitor by
> > > > Pfizer.
> > > >
> > > > Promising Evidence Uncovered
> > > > The trial is based on previous studies, both in animals and people,
that
> > > > have suggested that statins can alter immune responses and possibly
> > > > reduce inflammation. It's believed the cause of MS lies in an
abnormal
> > > > immune response that attacks the body's own tissue as if it were
> > > > foreign.1
> > > >
> > > > --
> > > > Zone 5 S Jersey USA Shade garden in a Japanese manner
> > > > Vision problems? http://www.ocutech.com/ we own two.
> > > > Tell folks where to get your files FREE at http://www.DropLoad.com
> > > > "oeuf tôt pique " Lover
> > > >
> >
> > Moby Thesaurus words for "serendipity³
> > accidentality, actuarial calculation, adventitiousness, break,
> > bringing to light, casual discovery, casualness, catching, chance,
> > chance discovery, destiny, detection, determination, determining,
> > disclosure, discovery, distinguishment, espial, excavation,
> > exhumation, exposure, fate, find, finding, finding out, flukiness,
> > fortuitousness, fortuity, fortune, gamble, good fortune, good luck,
> > hap, happenstance, happy chance, heedless hap, how they fall,
> > indeterminacy, indeterminateness, invention, law of averages,
> > locating, location, lot, luck, lucky strike, moira, opportunity,
> > principle of indeterminacy, probability, problematicness,
> > random sample, recognition, rediscovery, revelation, risk,
> > run of luck, spotting, statistical probability, strike, the breaks,
> > theory of probability, treasure trove, trouvaille, trove,
> > uncertainty, uncertainty principle, uncovering, unearthing,
> > whatever comes
> >
> >
> > Well no one would invest a cent in a mining operation based on
> > serendipity. No science there ! Then again uncertainty can work both
> > ways with unprofitable ways discounted in the world of business.
> >
> > Bill
>
> I¹m sorry about the add on.
>
> I¹d just add it is one thing to enjoy serendipity ( a favorite word of
> mine ;)) with petri dishes and quite another with a drug distributed
> to many folks.
>
> Bill
>
> --
> Zone 5 S Jersey USA Shade garden in a Japanese manner
> Vision problems? http://www.ocutech.com/ we own two.
> Tell folks where to get your files FREE at http://www.DropLoad.com
> "oeuf tôt pique " Lover
>


.

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