Re: Study: Statins Lower Advanced Prostate Cancer Risk

Susan <Susan@xxxxxxxxxxxxxx> wrote in part:

>x-no-archive: yes
>
>
>listener wrote:
>> "Juhana Harju" <shantigiri@xxxxxxxxxxxxx> wrote in
>> news:3cl274F6imrpjU1@xxxxxxxxxxxxxx:
>>
>>
>>>listener wrote:
>>>:: LOS ANGELES (Reuters) - Cholesterol-lowering drugs known as statins
>>>:: may slash a man's risk of advanced prostate cancer, according to
>>>:: research presented Monday.
>>>::
>>>:: A study that followed more than 34,000 men over 10 years found that
>>>:: men who used statins had half the risk of advanced prostate cancer
>>>:: and one- third the risk of fatal prostate cancer, compared with men
>>>:: who did not use the drugs.
>>>::
>>>:: Statins -- which include Pfizer Inc.'s $10 billion-a-year Lipitor,
>>>:: [...]
>>>
>>>There are definitely healthier and cheaper means to reduce prostate
>>>cancer risk than the use of statins.
>>>
>>
>>
>> OK. Please show us some studies using something other than a statin that
>> show tens of thousands of men over a multi-year period halving their risk
>> of advanced prostate cancer and lowering by one-third their risk of *fatal*
>> prostate cancer. I would be curious to read any legitimate studies you can
>> offer. Really.
>>
>> By the way, for those with medical insurance, statins are very inexpensive
>> and for those that do not experience side effects their "health-
>> worthiness" is not an issue.
>>
>> L.
>
>Lower insulinogenic diets, for starters. I understand your concern as
>an industry, really I do. If folks keep paying attention to the
>research, they won't need statins, beta cell stimulators or insulin
>sensitizers, just diet and exercise for most of us.
>
>Susan
>
>1: Int J Cancer. 2004 Nov 10;112(3):446-50. Related Articles, Links
> Click here to read
> Glycemic index, glycemic load and risk of prostate cancer.
>
> Augustin LS, Galeone C, Dal Maso L, Pelucchi C, Ramazzotti V,
>Jenkins DJ, Montella M, Talamini R, Negri E, Franceschi S, La Vecchia C.
>
> Department of Nutritional Sciences, Faculty of Medicine, University
>of Toronto, Toronto, Canada.
>
> Dietary carbohydrates have different glycemic and insulinemic
>potentials depending on type (glycemic index, GI) and amount (glycemic
>load, GL) of carbohydrate consumed or both. Insulin in turn has been
>implicated as a risk factor for several cancers, including that of the
>prostate. We assessed the relationship of GI and GL with prostate cancer
>risk in a multicenter case-control study. Cases and controls were
>recruited between 1991 and 2002 in the network of major teaching and
>general hospitals in 4 Italian areas. Cases were 1,204 men (age range
>46-74 years) admitted for incident, histologically confirmed prostate
>cancer. Controls were 1,352 men (age range 46-74 years) admitted for
>acute, nonmalignant conditions unrelated to long-term modifications of
>diet. ORs of prostate cancer and the corresponding 95% CIs were derived
>using unconditional multiple logistic regression, including terms for
>age, study center, education, family history of prostate cancer,
>smoking, body mass index, physical activity, alcohol consumption, intake
>of energy, fiber and lycopenes. Compared to the lowest quintile of GI,
>the ORs were 1.23, 1.24, 1.47 and 1.57 for subsequent levels of GI. The
>corresponding values for GL were 0.91, 1.00, 1.20 and 1.41. No
>heterogeneity was found among strata of selected covariates. We found
>direct relations between dietary GI and GL and prostate cancer risk.
>Correcting for potential confounding factors did not substantially
>modify these associations.
>
> Publication Types:
>
> * Multicenter Study
>
>
> PMID: 15382070 [PubMed - indexed for MEDLINE]

Interesting, though it is a case-control study (as is--I
think--the subject paper of this thread).

I wonder what the heck is meant by; "No
heterogeneity was found among strata of selected covariates." I'd
guess that any number of differences might be present between the
the controls and cases, including many no one has thought about.
The study says, "ORs of prostate cancer and the corresponding 95%
CIs were derived using unconditional multiple logistic regression,
including terms for age, study center, education, family history
of prostate cancer, smoking, body mass index, physical activity,
alcohol consumption, intake of energy, fiber and lycopenes." That
makes me want a prospective controlled trial.
--
Jim Chinnis Warrenton, Virginia, USA
.

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