Fish oil may harm defibrillator patients

CHICAGO (Reuters) - Fish oil appears to do more harm than good for heart
patients who have surgically implanted defibrillators to shock their
weakened hearts back into rhythm, researchers said on Tuesday.

In a study of 200 patients with the electrical devices, half took fish
oil supplements and the other half olive oil. Those who consumed fish oil
had more episodes of dangerous heart arrhythmia that often precede heart
attacks.

Fish oil -- whether absorbed from eating fish such as cod or in
supplement form -- has previously been found to reduce by about 25
percent the risk of fatal heart attacks in survivors of a previous
attack.

Scientists believe the omega-3 polyunsaturated fatty acids contained in
fish oil eases blood flow by reducing lipid levels in the blood. Fish
oil's ingredients may also induce changes in heart cell walls that
smooths passage of electrical charges that trigger heartbeats.

"We went into the study with the pretty strong belief that fish oil was
going to prevent arrhythmia and lessen the shocks that are so
uncomfortable," but records from the devices showed fish oil had the
opposite effect, study author Merritt Raitt of the Portland, Oregon,
Veterans Affairs Medical Center said in an interview.

Nearly two-thirds of the patients who took fish oil and suffered from
tachycardia, or rapid heartbeat, had episodes over a six-month period,
twice the rate of those taking a placebo. Forty-six percent of the
patients who suffered from fibrillation, where the heart flutters, and
who took fish oil had episodes compared to 36 percent of placebo-taking
patients.

"What may be happening is that fish oil in these patients is
proarrhythmic -- making these abnormal rhythms occur when they wouldn't
otherwise," Raitt told Reuters.

"Proarrhythmia is a danger with all drugs that affect heart rhythm and is
more common the sicker the heart is. So we may just be seeing this
particular drug, fish oil, is proarrhythmic in people who have
defibrillators."

Roughly 150,000 Americans each year receive the increasingly popular
defibrillators, a $5 billion market shared by Medtronic Inc., Guidant
Corp., and St. Jude Medical Inc.

Most defibrillator patients also take some type of heart medication,
though there are few studies examining the combination, Raitt said.

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