Re: Statin-associated Muscle Problems
- From: "Andrew B. Chung, MD/PhD" <andrew@xxxxxxxxxxxxxx>
- Date: Sun, 26 Jun 2005 20:41:26 -0400
Hawki63@xxxxxxxxxxxxx wrote:
>
> "Sharon Hope" <shope@xxxxxxxx> wrote in message
> news:VtydnTvviv_3cCPfRVn-qg@xxxxxxxxxxxxxx
> >
> > <Hawki63@xxxxxxxxxxxxx> wrote in message
> > news:Xjkve.4026$Bx6.2643@xxxxxxxxxxxxxxxxxxxxxxxxxxxxx
> >>
> >> "Sharon Hope" <shope@xxxxxxxx> wrote in message
> >> news:sd6dnU5kysuoSiHfRVn-oQ@xxxxxxxxxxxxxx
> >>> Yes, but did you have a muscle biopsy showing ragged red fibers? That,
> >>> due to a placebo effect, would be an apples to apples comparison for
> >>> those who have had such diagnosis of their statin myopathy.
> >>
> >>
> >> that makes no sense...even if I did have a muscle biopsy showing ragged
> >> red fibers,,,it could not be placebo effect..
> >>
> >> if never on a statin...such a biopsy could not be blamed on a statin
> >>
> >> or am I missing your drift??
> >
> > Actually you made my point.
> >
> > Yes, muscle pain is often just muscle pain.
> >
> > However, your muscle pain on placeboe would/did not bear up under
> > diagnosis.
> >
> > It is difficult (even with the pain scale) to compare pain among patients.
> > Some patients actually commit suicide due to chronic pain (a friend of a
> > friend IME). Others withstand incredible pain.
> >
> > Your anecdote about the pain was interesting, and a remider of the placebo
> > effect (and its inverse).
> >
> > However, I was trying to remind you that what you considered pain may or
> > may not compare to other statin patient's muscle pain.
> >
> > I've told it before, but my husband's explanation of his statin pain came
> > up in the course of bumping his finger. He had that morning reached to
> > pick up a fallen palm frond and accidentally jammed a splinter from the
> > stalk end (about the width & thickness of the wide end of a flat
> > toothpick) up under his fingernail and all the way through longitudinally
> > to the quick, erupting through the skin at that end of the nail. Palm
> > fronds are fibrous and expand with moisture, so the splinter swelled,
> > adding pressure under the nail, and attempts to remove it left some pieces
> > under the nail.
> >
> > Later in the day, as he reached for something and bumped the finger he
> > expressed pain, then turned to me to explain. You know, he said, this
> > finger really hurts, but the level of constant pain I am in from the
> > Lipitor is so high that, except for the moment when I got the splinter,
> > and times like this when I actually bump it, the pain from this splinter
> > is low enough by comparison that it is overcome by the chronic pain I feel
> > every hour, day and night, from the statin.
> >
> > Maybe your placebo pain was that strong, but I doubt it. Maybe your
> > placebo pain went on for over 7 1/2 years, as my husband's Lipitor pain
> > has - every minute of every day, 24 hours per day, 365 days per year, 366
> > on leap years - but I doubt it.
> >
> > And, certainly as you have confirmed, your placebo pain was not confirmed
> > by muscle biopsy to be structurally demonstrable, as is the muscle pain of
> > countless statin myopathy and myositis sufferers.
> >
> > Nor, although you do not say so, was your muscle pain confirmed to be
> > myopathy due to statin-induced mitochondrial dysfunction as confirmed by
> > chromatographic evaluation of exhalation gasses on a treadmill, as was my
> > husband's Lipitor-induced myopathy, myositis, and mitochondrial damage.
> >
> > Therefore, although you point is a good reminder that sometimes we can
> > talk ourselves into a cause for muscle pain that may just have been the
> > result of normal daily life, it is very wrong of you to imply to a person
> > who is taking statins and publicly complaining of muscle pain that they,
> > like you, may just be imagining the cause to be statin adverse effects.
> >
> > 1) The degree of pain is not comparable
> > 2) There is the option of muscle biopsy to show statin muscular and
> > mitochondrial damage
> > 3) There are metabolic tests to show statin mitochondrial damage
> > 4) There are the published statistics that show (most recently published
> > by paper presentation at the International CoQ10 Society conference, the
> > Canadian radio broadcast on statins, and Dr. Cohen's book) that muscle
> > pain and muscle damage is the #1 adverse effect of statins and of the 3
> > most common adverse effects of statins - muscle, cognitive, and
> > neurological damage - patients are experiencing at least one of the three
> > at a rate of between 15% to 30%.
> >
> > Thus, even though you had some muscle pain and were not on a statin, that
> > fact does nothing to discredit the pain felt by those on statins.
> > Further, it is ABSOLUTELY NOT proof that their pain is unrelated to the
> > statin.
> >
> > As a nurse you are certainly a humanitarian, and I know you did not mean
> > to imply you were disputing the person with muscle pain statin adverse
> > effects. I just wanted to help you make that fact clear.
> >
>
> thanks for that Sharon...you said it more clearly than I
>
> the past few days have given me a new understanding of pain...I broke a bone
> in my foot...on a scale of 1-10..the pain was at least a 15!!
>
> luckily it is beginning to diminish..
Nothing in this universe occurs by chance as Dr. **Jeff** Utz would have
people believe.
Would suggest you stop worshipping luck, which is sinning.
> I now can hobble around with the
> cast...the Percocet was actually making the situation worse..as it made my
> chronic headaches much worse and I was sooooo nauseated!!
>
> who woulda thunk a small foot bone fracture could hurt like that??? it
> did..
The Lord has chastened you so that others will now know He is God. Now
imagine your pain amplified **more** than 1000 fold. That will be your
suffering if you reject His salvation unto your death.
Meanwhile, you will remain in my prayers to our heavenly Father, dear
neighbor whom I love in Lord Jesus' most precious and holy name, because
you know not what you are doing.
May He continue to touch your life in special ways so that you will be
drawn closer to Him.
In Christ's love and service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?G1D5217EA
(2) http://makeashorterlink.com/?W13A4250B
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
.
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