Re: CK blood test


"Robert" <Robertitsme@xxxxxxxxxxx> wrote in message
news:FOednZk6qqRJz1XfRVn-qQ@xxxxxxxxxx
> http://jnnp.bmjjournals.com/cgi/content/full/68/6/750
>
> http://www.gpnotebook.co.uk/cache/-415956920.htm
>
> Being a doctor is hard and not as straight forward as some would have you
> believe.
>
> Statins are contra indicated in hypothyroidism which is what I presume you
> have based on your Super sensitive TSH which is low. Thyroid meds are
> based
> on TSH levels. Too low then meds are cut back and too high then meds are
> increased.
> Thyroid impacts metabolism. You know how people go on diets and they say
> to
> lose fat and not muscle? Muscle metabolism is involved in thyroid
> disorders
> as reflected by the CK or CPK which stands for creatine phosphokinase. It
> is
> an enzyme that is involved with high energy phosphorulation coupling
> reactions. ATP is the energy source of preference for aerobic use while
> creatine phosphate is the preferred source for anaerobic function.
>
> There are three different enzymes that we can test for. The one of use
> clinically is the CKMB fraction that is derived from heart generally and
> is
> used to check for heart attacks. The CKMM fraction is from conventional
> muscle and the CKBB fraction from brain.
>
> There are many, many reasons for CK elevations, from regular exercise to
> more severe disease.
>
> To blame everything on statins is just as dangerous and not blaming
> anything
> on statins.
>
>

Yes, the doctors are supposed to look for "horses, not zebras" in
identifying the cause of a problem.

In this case, the doctor should first ask, did you participate in an
ultra-marathon race immediately before the blood test?

If not, the "horse" approach would be to ask:

Is this patient taking a drug that has a known adverse effect of muscle
damage as identified by elevated CK? Yes? A statin? Then the most likely
cause is the statin.

If no statin has been taken, and no other myotoxin, look for the next most
likely cause of the elevated CK.


If, by the way, the statin was discontinued due to muscle pain, expect the
muscle pain and damage to continue for months to years before subsiding. CK
elevation can continue to climb for a full year before leveling off and then
subsiding.

In some cases, the statin muscle damage exists without the elevated CK.

In many cases, some level of statin-induced muscle dysfunction is permanent.

> "Ben" <organ@xxxxxxxx> wrote in message
> news:da9db30o1c@xxxxxxxxxxxxxxxxxxxxx
>> Hi Everyone
>>
>> I had full blood work done a few weeks ago and most of the result was
>> very
>> good. Especially the cholesterol. but two readings were out of the normal
>> limits. And that is STSH 0.08, that is for the thyroid. which is not
> working
>> well due that I am on Amiodarone and also the CK 390. Now the
>> cardiologist
>> reduce my thyroid medication, but said nothing about the CK.
>> My question is, are the two related, what is CK reading anyway?
>> Your input would be appreciated
>> Ben
>>
>>
>>
>
>


.

Relevant Pages

  • Re: CK blood test
    ... >> Thyroid impacts metabolism. ... Muscle metabolism is involved in thyroid disorders ... >> There are many, many reasons for CK elevations, from regular exercise to ... > cause is the statin. ...
    (sci.med.cardiology)
  • Re: Quiting statin drugs
    ... Those muscle problems that do not show up in the blood ... >> reverse quickly if the statin was the cause. ... > CK Blood Test Inadequate to Diagnose Statin-Associated Myopathy ... > patients with myopathy have muscle tenderness and weakness. ...
    (sci.med.cardiology)
  • Re: Statins, CoQ10 and CRP
    ... and this increased my muscle soreness. ... Obtain a CK measurement if the patient reports suggestive muscle symptoms, ... Discontinue statin therapy (or statin and niacin or fibrate if the patient ... Rhabdomyolysis is destruction of muscle with elevations of CK along with ...
    (sci.med.cardiology)
  • Re: Quiting statin drugs
    ... Those muscle problems that do not show up in the blood ... Statin-Associated Myopathy with Normal Creatine Kinase Levels, ... One statin was taken off the market because patients ...
    (sci.med.cardiology)
  • Re: Quiting statin drugs
    ... >> one known side effect of statins is a muscle condition called ... One statin was taken off the market because ... >> patients frequently developed myopathy while taking it, ... >> patients with myopathy have muscle tenderness and weakness. ...
    (sci.med.cardiology)
Loading