Re: CK blood test


"Sharon Hope" <shope@xxxxxxxx> wrote in message
news:W9idnfLmY7EBHlXfRVn-pg@xxxxxxxxxxxxxx
>
> "Robert" <Robertitsme@xxxxxxxxxxx> wrote in message
> news:FOednZk6qqRJz1XfRVn-qQ@xxxxxxxxxx
>> http://jnnp.bmjjournals.com/cgi/content/full/68/6/750
>>
>> http://www.gpnotebook.co.uk/cache/-415956920.htm
>>
>> Being a doctor is hard and not as straight forward as some would have you
>> believe.
>>
>> Statins are contra indicated in hypothyroidism which is what I presume you
>> have based on your Super sensitive TSH which is low. Thyroid meds are based
>> on TSH levels. Too low then meds are cut back and too high then meds are
>> increased.
>> Thyroid impacts metabolism. You know how people go on diets and they say to
>> lose fat and not muscle? Muscle metabolism is involved in thyroid disorders
>> as reflected by the CK or CPK which stands for creatine phosphokinase. It
>> is
>> an enzyme that is involved with high energy phosphorulation coupling
>> reactions. ATP is the energy source of preference for aerobic use while
>> creatine phosphate is the preferred source for anaerobic function.
>>
>> There are three different enzymes that we can test for. The one of use
>> clinically is the CKMB fraction that is derived from heart generally and is
>> used to check for heart attacks. The CKMM fraction is from conventional
>> muscle and the CKBB fraction from brain.
>>
>> There are many, many reasons for CK elevations, from regular exercise to
>> more severe disease.
>>
>> To blame everything on statins is just as dangerous and not blaming
>> anything
>> on statins.
>>
>>
>
> Yes, the doctors are supposed to look for "horses, not zebras" in
> identifying the cause of a problem.
>
> In this case, the doctor should first ask, did you participate in an
> ultra-marathon race immediately before the blood test?
>
> If not, the "horse" approach would be to ask:
>
> Is this patient taking a drug that has a known adverse effect of muscle
> damage as identified by elevated CK? Yes? A statin? Then the most likely
> cause is the statin.
>


I don't know if that is true or not true. What do you base that on? Do you
know what % of people who are not on statins normally have high CK levels?
Thanks.


> If no statin has been taken, and no other myotoxin, look for the next most
> likely cause of the elevated CK.
>
>
> If, by the way, the statin was discontinued due to muscle pain, expect the
> muscle pain and damage to continue for months to years before subsiding.

Just the opposite is true. From

http://medicine.ucsd.edu/SES/adverse_effects.htm

"Although symptoms usually resolve on stopping the drug, for a proportion of
those who have contacted us, muscle symptoms ? pain or weakness ? or
peripheral neuropathy may persist when the drugs are discontinued."





>CK elevation can continue to climb for a full year before leveling off and
>then subsiding.
>
> In some cases, the statin muscle damage exists without the elevated CK.
>
> In many cases, some level of statin-induced muscle dysfunction is permanent.
>

I don't think there has been any documented case of permanent muscle damage
without elevated CK levels. Do you have any evidence that such cases exist?

Bill

>> "Ben" <organ@xxxxxxxx> wrote in message
>> news:da9db30o1c@xxxxxxxxxxxxxxxxxxxxx
>>> Hi Everyone
>>>
>>> I had full blood work done a few weeks ago and most of the result was very
>>> good. Especially the cholesterol. but two readings were out of the normal
>>> limits. And that is STSH 0.08, that is for the thyroid. which is not
>> working
>>> well due that I am on Amiodarone and also the CK 390. Now the cardiologist
>>> reduce my thyroid medication, but said nothing about the CK.
>>> My question is, are the two related, what is CK reading anyway?
>>> Your input would be appreciated
>>> Ben
>>>
>>>
>>>
>>
>>
>
>


.

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