Re: statins don't reduce dementia risk


"Jim Chinnis" <jchinnis@xxxxxxxxxxxxxxxx> wrote in message
news:dhegd1l6sq5dhjcni357vkb1vchjuc9q88@xxxxxxxxxx
> tonywesley@xxxxxxxxx wrote in part:
>
>>
>>Jim Chinnis wrote:
>>> tonywesley@xxxxxxxxx wrote in part:
>>> >Well, one could contend that it would be at the same rate at those who
>>> >never took statins.
>>
>>> That's what the journalists do, and the PR folks when it fits
>>> their message.
>>
>>I thought that what researchers did. First the hypothesis, then
>>retrospective test, and if warrented, the prospective test.
>
> Competent researchers don't contend that the two arms of a
> retrospective study are the same in the way they would be in a
> randomized trial.
>
>>> > But until we do the randomized double-blind tests,
>>> >we won't know.
>>>
>>> Right.
>>
>>> >Looking at the abstract
>>> > http://archneur.ama-assn.org/cgi/content/short/62/7/1047
>>> >I found this interesting:
>>> > "... in secondary analyses, current use of statins compared with
>>> >nonuse of LLAs was associated with HRs of 0.69 (95% CI, 0.46-1.02) for
>>> >all-cause dementia and 0.56 (95% CI, 0.35-0.92) for any Alzheimer
>>> >disease."
>>>
>>> Yeah, the only statistically significant finding is that people
>>> with Alzheimer's aren't currently taking statins. Big surprise!
>>
>>Why isn't it a surpise to you? What's your theory on cause and effect?
>
> Well, it's not surprising to me those with Alzheimer's may decline
> to take (or not be prescribed) statins. If i were diagnosed with
> Alzheimer's and then my internist told me my cholesterol was high
> and my family history was bad for heart disease and pulled out his
> prescription pad, I don't think I'd bother.
>
>>This is the only prospective randomized test on the statin/AD
>>relationship that I'm aware of:
>>
>>http://www.alzforum.org/new/detail.asp?id=1194
>>
>>"The study, led by Larry Sparks at the Sun Health Research Institution
>>in Sun City, Arizona, and just published in the May Archives of
>>Neurology, produced significantly better scores on several measures of
>>cognitive function in atorvastatin-treated patients compared to the
>>placebo group."
>>
>>One of the comments is "it may be that statins reduce AD progression,
>>rather than decrease disease incidence."
>
> The scores were "significantly better" but the difference was not
> statistically significant. There was a trend, and if it continues,
> the full study will conclude that Lipitor is effective in treating
> Alzheimer's.
>
> But, of course, we don't know where the data will come out yet.
> Nonetheless, I'd weigh Spark's preliminary results more heavily
> than the results from any number of observational studies.

And keep in mind that per his publication, he washed out an inordinate and
unexpected number of statin participants due to adverse effects.

Further, there was no stated procedure on how he would differentiate between
patients suffering Alzheimers and those who developed dementia solely due to
a statin adverse effect. In fact, the distinction was not made at all for
the study.

How can you trust a study that uses a known dementia-causing substance
investigating if it prevents a different type of dementia, without any
acknowledgement of the dementia it is known to cause and no procedure or
methodology offered on how to distinguish between the two types of dementia?

> --
> Jim Chinnis Warrenton, Virginia, USA


.

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