Re: statins don't reduce dementia risk


"Sharon Hope" <shope@xxxxxxxx> wrote in message
news:CMydnZtpKc2_CkXfRVn-gw@xxxxxxxxxxxxxx
>
> <tonywesley@xxxxxxxxx> wrote in message
> news:1121407960.321980.4990@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
>> Jim Chinnis wrote:
>>> tonywesley@xxxxxxxxx wrote in part:
>>>
>>> >zee wrote:
>>> >> http://www.psycport.com/showArticle.cfm?xmlFile=usatoday_2005_07_12_eng-usatoday_life_eng-usatoday_life_021529_7391647621957932886.ew.xml&provider=USA%20TODAY
>>> >>
>>> >> "To get more proof, researchers will have to give a large number of
>>> >> middle-aged people either statins or placebo pills and then check to
>>> >> see whether the people getting the statins are shielded from the
>>> >> disease years later."
>>> >>
>>> >>
>>> >> <<speechless>>
>>
>>> >Another quote from that URL:
>>> >
>>> >"Participants took cognitive and memory tests throughout the study. The
>>> >researchers found that those who took statins developed dementia or
>>> >Alzheimer's at about the same rate as those who were not taking the
>>> >drugs."
>>
>>> Yeah, but the difficulty is that you don't know how many of the
>>> statin consumers would have developed dementia if they HADN'T
>>> taken the statin. It's anybody's guess.
>>
>> Well, one could contend that it would be at the same rate at those who
>> never took statins. But until we do the randomized double-blind tests,
>> we won't know.
>
> However, don't count out the fact that the dementia caused by statin adverse
> effects is able to be diagnosed in a way that rules out Alzheimers, for
> example.
>
> So, the number of people who would have developed Alzheimers anyway is no
> more pertinent than the number of people who would have developed any other
> unrelated condition.
>
> For those dementias like Picks, which can only be diagnosed by biopsy or
> autopsy, there is still a differential diagnosis possible, because people
> who halt the statins and recover (even a little bit) would not be recovering
> had the dementia been Picks.
>
> This is a dementia caused by statins. That it exists and can be diagnosed
> via differential diagnosis is in and of itself a proof of existence.

Could you provide a reference for that. Thanks.

Bill

> If it is a demential unique to statin adverse effects, you would expect none
> of the non-statin-taking population (and non-red yeast rice-taking
> population) to develop that particular type of dementia, and other types
> would be unrelated (except, perhaps, as an indicator of who might be
> predisposed to a dementia expression).
>
> Certainly, if you could identify a naturally occurring dementia that was
> comparable, then the 'gold standard' would apply, but so far that hasn't
> been the case with statin dementia.
>
> Typically, with the more extreme statin adverse effects, only pediatricians
> are familiar with the constellation of symptoms, because only infants having
> some extreme congenital lipid processing defect, or mitochondrial defect or
> CoQ10 deficiency exhibit them. These infants either have the condition
> corrected, or they do not become adults. Thus, adult doctors are at such a
> loss when presented by these 'rare' constellations of symptoms.
>
>>
>> Looking at the abstract
>> http://archneur.ama-assn.org/cgi/content/short/62/7/1047
>> I found this interesting:
>> "... in secondary analyses, current use of statins compared with
>> nonuse of LLAs was associated with HRs of 0.69 (95% CI, 0.46-1.02) for
>> all-cause dementia and 0.56 (95% CI, 0.35-0.92) for any Alzheimer
>> disease."
>>
>
>


.

Relevant Pages

  • Re: statins dont reduce dementia risk
    ... >>> adverse effects is able to be diagnosed in a way that rules out ... >>> recovering had the dementia been Picks. ... >>> via differential diagnosis is in and of itself a proof of existence. ... Differential diagnosis makes it the statin. ...
    (sci.med.cardiology)
  • Re: Statins do NOT protect against Azlheimers
    ... Statin therapy and risk ... of dementia in the elderly: ... > Do statins reduce risk of incident dementia and Alzheimer disease? ...
    (sci.med.cardiology)
  • Re: statins dont reduce dementia risk
    ... >> statin consumers would have developed dementia if they HADN'T ... via differential diagnosis is in and of itself a proof of existence. ...
    (sci.med.cardiology)
  • Re: Statins do NOT protect against Azlheimers
    ... Do statins reduce risk of incident dementia and Alzheimer disease? ... relate statin use and dementia incidence. ... of statin use with both prevalence and incidence of dementia and AD. DESIGN: ...
    (sci.med.cardiology)
  • Re: CABG Alzhelimers Study
    ... > which have looked for cognitive decline in statin users in very large ... > that since statins decrease stroke and death, ... > compensate for a direct drug-induced dementia in statin takers. ...
    (sci.med.cardiology)
Quantcast