Re: statins don't reduce dementia risk


"Bill" <xxx@xxxxx> wrote in message
news:G72Ce.2864$8y1.1260@xxxxxxxxxxxxxxxxxxxxxxxxxxxxx
>
> "Sharon Hope" <shope@xxxxxxxx> wrote in message
> news:CMydnZtpKc2_CkXfRVn-gw@xxxxxxxxxxxxxx
>>
>> <tonywesley@xxxxxxxxx> wrote in message
>> news:1121407960.321980.4990@xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
>>> Jim Chinnis wrote:
>>>> tonywesley@xxxxxxxxx wrote in part:
>>>>
>>>> >zee wrote:
>>>> >> http://www.psycport.com/showArticle.cfm?xmlFile=usatoday_2005_07_12_eng-usatoday_life_eng-usatoday_life_021529_7391647621957932886.ew.xml&provider=USA%20TODAY
>>>> >>
>>>> >> "To get more proof, researchers will have to give a large number of
>>>> >> middle-aged people either statins or placebo pills and then check to
>>>> >> see whether the people getting the statins are shielded from the
>>>> >> disease years later."
>>>> >>
>>>> >>
>>>> >> <<speechless>>
>>>
>>>> >Another quote from that URL:
>>>> >
>>>> >"Participants took cognitive and memory tests throughout the study.
>>>> >The
>>>> >researchers found that those who took statins developed dementia or
>>>> >Alzheimer's at about the same rate as those who were not taking the
>>>> >drugs."
>>>
>>>> Yeah, but the difficulty is that you don't know how many of the
>>>> statin consumers would have developed dementia if they HADN'T
>>>> taken the statin. It's anybody's guess.
>>>
>>> Well, one could contend that it would be at the same rate at those who
>>> never took statins. But until we do the randomized double-blind tests,
>>> we won't know.
>>
>> However, don't count out the fact that the dementia caused by statin
>> adverse effects is able to be diagnosed in a way that rules out
>> Alzheimers, for example.
>>
>> So, the number of people who would have developed Alzheimers anyway is no
>> more pertinent than the number of people who would have developed any
>> other unrelated condition.
>>
>> For those dementias like Picks, which can only be diagnosed by biopsy or
>> autopsy, there is still a differential diagnosis possible, because people
>> who halt the statins and recover (even a little bit) would not be
>> recovering had the dementia been Picks.
>>
>> This is a dementia caused by statins. That it exists and can be
>> diagnosed via differential diagnosis is in and of itself a proof of
>> existence.
>
> Could you provide a reference for that. Thanks.

My husband's case is the prime example in my life. Alzheimer's, tau, and
other dementias were ruled out. Differential diagnosis makes it the statin.
Further, the s...l...o.....w recovery upon halting of statin, even though it
is not complete, is further evidence that the various degenerative dementias
are not in play - because they are degenerative.

Many many specialist exams and tests, and continuing monitoring and testing
clearly demonstrate this.

I know of others who have experienced the same statin-caused dementia
adverse effects sequence.

There is a difference.

What is similar, however, is the effect on the quality of life of the
individual experiencing memory loss, confusion, amnesia, "big ragged black
holes" in memory.

On any given day, a person who has active statin-caused dementia has to deal
with this has the same functional and emotional impact from the memory loss
as someone with Alzheimer's regardless of cause.

However, in the longer term, the major difference is that those with the
degenerative diseases that cause dementia continue to decline. So although
their symptoms are similar to the statin-caused dementia adverse effects,
there is no known way proven to halt the progression (yet). With the
statin-caused dementia adverse effects, there is recovery possible up to 80%
of the original pre-statin cognitive abilities, per Dr. Golomb's research
presented at the International Coenzyme Q10 Association conference this
year.

In no way am I trying to minimize the emotional impact on the families of
the Alz patient, as they know it is fatal.

However, the families of patients suffering dementia from statin adverse
effects, are affected by uncertainties and outrage, knowing it SHOULD HAVE
BEEN PREVENTED, and that there is no treatment, and that the net effects are
just as disabling and hurtful as Alz, and there is no reliable prognosis, is
also extremely difficult. Yes, we do rejoice that it is not fatal, and
after years of waiting we rejoice in the smallest of improvements, but it is
still a very difficult time.

>
> Bill
>
>> If it is a demential unique to statin adverse effects, you would expect
>> none of the non-statin-taking population (and non-red yeast rice-taking
>> population) to develop that particular type of dementia, and other types
>> would be unrelated (except, perhaps, as an indicator of who might be
>> predisposed to a dementia expression).
>>
>> Certainly, if you could identify a naturally occurring dementia that was
>> comparable, then the 'gold standard' would apply, but so far that hasn't
>> been the case with statin dementia.
>>
>> Typically, with the more extreme statin adverse effects, only
>> pediatricians are familiar with the constellation of symptoms, because
>> only infants having some extreme congenital lipid processing defect, or
>> mitochondrial defect or CoQ10 deficiency exhibit them. These infants
>> either have the condition corrected, or they do not become adults. Thus,
>> adult doctors are at such a loss when presented by these 'rare'
>> constellations of symptoms.
>>
>>>
>>> Looking at the abstract
>>> http://archneur.ama-assn.org/cgi/content/short/62/7/1047
>>> I found this interesting:
>>> "... in secondary analyses, current use of statins compared with
>>> nonuse of LLAs was associated with HRs of 0.69 (95% CI, 0.46-1.02) for
>>> all-cause dementia and 0.56 (95% CI, 0.35-0.92) for any Alzheimer
>>> disease."
>>>
>>
>>
>
>


.

Relevant Pages

  • Re: statins dont reduce dementia risk
    ... >>> adverse effects is able to be diagnosed in a way that rules out ... >>> recovering had the dementia been Picks. ... >>> via differential diagnosis is in and of itself a proof of existence. ... Differential diagnosis makes it the statin. ...
    (sci.med.cardiology)
  • Re: Statins do NOT protect against Azlheimers
    ... Statin therapy and risk ... of dementia in the elderly: ... > Do statins reduce risk of incident dementia and Alzheimer disease? ...
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  • Re: Statins do NOT protect against Azlheimers
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  • Re: CABG Alzhelimers Study
    ... > which have looked for cognitive decline in statin users in very large ... > that since statins decrease stroke and death, ... > compensate for a direct drug-induced dementia in statin takers. ...
    (sci.med.cardiology)
  • Re: CABG Alzhelimers Study
    ... > which have looked for cognitive decline in statin users in very large ... > that since statins decrease stroke and death, ... > compensate for a direct drug-induced dementia in statin takers. ...
    (sci.med.cardiology)
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