Re: CABG Alzhelimer's Study

In article
<PainInAss__williamwag-5E3DC6.04592725082005@xxxxxxxxxxxxxxxxxx>,
William Wagner <PainInAss__williamwag@xxxxxxxxx> wrote:

> http://www.eurekalert.org/
>
>
> Public release date: 25-Aug-2005
> [ Print Article | E-mail Article | Close Window ]
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> Contact: Kristen Perfetuo
> kristen.perfetuo@xxxxxxx
> 617-638-8491
> Case Western Reserve University
>
> New research suggests heart bypass surgery increases risk of Alzheimer's
> disease
> Researchers say stress and trauma of surgery may be to blame
> Boston University School of Medicine (BUSM) researchers have discovered
> that patients who have either coronary artery bypass graft surgery or
> coronary angioplasty are at an increased risk of developing Alzheimer's
> disease.
> The research, which appears in the current issue of the Journal of
> Alzheimer's Disease (http://www.j-alz.com), pinpoints stress and trauma
> of the surgery as the major cause for the increased risk.
> Led by Benjamin Wolozin, MD, PhD, professor of pharmacology at BUSM,
> researchers compared 5,216 people who underwent coronary artery bypass
> graft surgery (CABG) and 3,954 people who had a percutaneous
> transluminal coronary angioplasty (PTCA) in 1996 and 1997. Over the
> course of five years, 78 of the patients who had bypass surgery and 41
> of those who had angioplasty developed Alzheimer's disease.
> "The coronary bypass patients had a 70 percent increased risk of
> developing Alzheimer's disease," said Wolozin, co-author of the study.
> "This increased incidence of neurocognitive degeneration associated with
> heart bypass surgery provides further incentive for more studies to
> better characterize the risks of cardiac surgery on the brain."
> According to Wolozin, previous studies show some heart surgery patients
> experience memory problems immediately following the procedure. However,
> at a one-year follow-up most patients regain cognitive function.
> Researchers believe this early cognitive impairment is an immediate
> reaction to the stress of surgery.
> "Heart bypass surgery represents a traumatic insult to the brain,
> particularly by reducing oxygen supply to the brain and increasing the
> stress response," said Wolozin.
> "We believe that the compensation that occurs by one year masks an
> underlying deficit in the central nervous system caused by the heart
> surgery. As individuals age, this underlying deficit might exacerbate
> progressive cognitive deficits associated with mild cognitive
> impairment, a precursory phase before diagnosis of Alzheimer's."
> Wolozin and his researchers are currently working with researchers from
> the Framingham Heart Study to determine if these same observations can
> be duplicated in their studies.
> "If these observations are confirmed, there are measures that can be
> taken to protect the brain during heart bypass surgery," explained
> Wolozin. "Antioxidants might offer some protection, as well as
> memantine, a medication that helps slow the progression of Alzheimer's
> disease. There may also be other neuroprotective agents still in
> development that could shield the brain from cognitive degeneration
> during and following surgery."
>
> ###
> The article is "Assessment of the Emergence of Alzheimer's Disease
> Following Coronary Artery Bypass Graft Surgery or Percutaneous
> Transluminal Coronary Angioplasty" by Todd A. Lee, Benjamin Wolozin,
> Kevin B. Weiss and Martin M. Bednar (Communicated by Craig Atwood). It
> appears in the Journal of Alzheimer's Disease, Vol. 7, Number 4
> published by IOS Press.
> About the Journal of Alzheimer's Disease
> The Journal of Alzheimer's Disease (www.j-alz.com) is an international
> multidisciplinary journal to facilitate progress in understanding the
> etiology, pathogenesis, epidemiology, genetics, behavior, treatment and
> psychology of Alzheimer's disease. The journal publishes research
> reports, reviews, short communications, book reviews, and
> letters-to-the-editor. The journal is dedicated to providing an open
> forum for original research that will expedite our fundamental
> understanding of Alzheimer's disease.
> About IOS Press
> Commencing its publishing activities in 1987, IOS Press
> (www.iospress.com) is a rapidly expanding scientific, technical, medical
> and professional publishing house focusing on a broad range of subject
> areas. Headquartered in Amsterdam, IOS Press publishes approximately 100
> new books per annum and 70 international journals, covering topics
> ranging from computer science and mathematics to medicine and the
> natural sciences. Electronic access to all journals is now available.
> IOS Press also maintains offices in the Washington, DC area and Berlin
> and a co-publishing relationship with Ohmsha, Ltd (Tokyo).
>
>
>
> [ Print Article | E-mail Article | Close Window ]
>
>  

First of all I'm sorry for Alzheimer's misspell.

Here are my concerns that are growing.

1) Cabg can enhance the risk of Alzheimer's AKA Cognitive disorder.
Good to know yet risk may justify.

2) Beta blockers are now being used to alleviate mental
distress/disorder. Guess bad memories are discerned from the good? Ha
Ha

3) Statins and possible Cognitive Disorder spoke about fought over.



That¹s three interventions that seem to be not of matter or cause
problems. . Measuring the effect are subjective unless we live it . Any
suggestions for best practices? They 1,2,3 keep on showing up! ALL
THREE ARE GIVEN TO FOLKS THAT NEEDED CABG.

A Subjective analysis by ME.

All these risks are they ever added up concerning our minds?


Bill

--
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