Re: CABG Alzhelimer's Study

Jim,

Your point that there is only a small difference in some of the tests is
well taken, but the study gave a snapshot at 6 months of a drug that is
supposed to be taken for life.

I know, because I have seen it, that the deficit increases with time on the
treatment. This is an early warning test.

When you live with a high-achieving high-functioning type-A who degrades
during 4 years of Lipitor to below the 1percentile, there is no doubt that
at 6 months there was no 'meaningful' loss, but a measurable loss. Had we
had a test to warn at 6 months that the damage was already under way, that
would have been 'significant' information, even if the cognitive damage at
that time was not considered 'significant.'

Now, after 3 + years off the Lipitor and cognitive rehabilitation therapy,
it is 'impaired.'

Preventable life-altering damage, for which we did not have the luxury of
early warning. Now that early warning is on record - in 3 different tests
during 2 different trials.

"Jim Chinnis" <jchinnis@xxxxxxxxxxxxxxxx> wrote in message
news:jrgug1d64khu7bq7ohicgo49db5t1qo365@xxxxxxxxxx
> "Sharon Hope" <shope@xxxxxxxx> wrote in part:
>
>>>>3) Statins and possible Cognitive Disorder spoke about fought over.
>>>
>>> There is no randomized study that has shown any meaningful loss of
>>> cognitive
>>> function from statins. Yes, there are adverse event reports. Not the
>>> same
>>> thing.
>>>
>>
>>And Muldoon's placebo controlled studies showing repeatedly that different
>>statins and the same statin at different dosages cause measurable
>>cognitive
>>deficit or failure to learn at a normal rate after only 6 months.
>
> Look at any one of the "statin-sensitive" test results. Take Digit
> Vigilance, for instance. oops, on that "statin sensitive" test, the
> statin-treated group improved more than the placebo group did. Let's try
> again. Take the next "statin sensitive" test, which is the Recurrent Words
> test (% correct). In that case, the statin group got 84% correct at
> baseline
> and 85% correct after being drugged with simvastatin for 6 months. But the
> control group got 80% correct at first and then bounced to 83% after 6
> months in the retest. So the statin group improved got 1% more words
> correct
> after 6 months and the placebo folks got 3% more correct.
>
> If you look at the 95% confidence intervals, you'll see that the
> post-treatment placebo group got between 80 and 86% right and the
> post-treatment statin group got between 83 and 86% right!
>
> Like I said, "There is no randomized study that has shown any meaningful
> loss of cognitive function from statins."
> --
> Jim Chinnis Warrenton, Virginia, USA


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