Re: Statin drugs lower heart attack death-study


"Sharon Hope" <shope@xxxxxxxx> wrote in message
news:r_WdncILH4CxnojeRVn-1w@xxxxxxxxxxxxxx
>
> "Bill" <xxx@xxxxx> wrote in message
> news:vNQQe.1226$oJ2.657@xxxxxxxxxxxxxxxxxxxxxxxxxxxxx
>>
>> "listener" <listener@xxxxxxxxxx> wrote in message
>> news:Xns96C1ECF7D8E52some1outthere@xxxxxxxxxxxxxxxxx
>>> They aren't "talking" about it. They actually "did" it. And what's so
>>> surprising about it?
>>>
>>> "Patients who had not been prescribed statins in the past but were
>>> given one within 24 hours of hospitalization were 58 percent less
>>> likely to die." So, knowing that, if you ended up in the hosptial with an
>>> MI (god forbid) and they said "Here, take this statin" would you say to
>>> the doctor "No!please read Dr. Jay Cohen's book WHAT YOU MUST KNOW ABOUT
>>> STATIN DRUGS AND THEIR NATURAL ALTERNATIVES and this 80 page document put
>>> together by Sharon Hope. Thank you."
>>>
>>> L.
>>>
>>
>> Obviously what I meant is that they were talking about it in the article -
>> clearly the people that ran the study did the testing.
>
> Bill - SHAME ON YOU - You have misrepresented the study by providing
> incomplete information.
>

I copied the entire article as is. You had a different article.

> THERE WAS NO TESTING. This was a research paper. This was NOT a trial, but
> was merely an observational anecdotal research study.
>

In what way anecdotal?

> "The researchers analyzed data from 174,635 heart attacks compiled as part
> of a national registry from July 2000 to January 2002."
>
> "Fonarow said a controlled clinical trial would be needed to confirm the
> findings, which were published in the American Journal of Cardiology."
>
> Bill - You did NOT present the factors they used to include or eliminate
> cases.
>

I simply copied the articles as they were in front of me. And my only comment
was surprise at the results. I could not present what I did not have.

> "He questioned the mechanism that the authors proposed to explain their
> findings.
>
> "Whether you get a benefit in the first 24 hours is pretty dubious," Shah
> said.
>
> Dr. Bruce M. Psaty, a University of Washington epidemiologist, said he
> thought that the results were flawed because too many factors complicated
> the analysis.
>
> For example, the most critically ill patients, whose treatment is focused on
> preventing imminent death, were probably the least likely to be prescribed a
> pill immediately after admission to the hospital, he said."
>
>
> http://www.latimes.com/news/science/la-sci-statins30aug30,0,7056171.story?coll=la-home-science
>
> AND Bill - You did NOT include the fact that anyone who took statins and
> could not tolerate them had a HIGHER death rate:
>
> "For patients who had been on the drugs but did not take them immediately
> after their attacks, the death rate rose 25% over patients who had never
> been on statins."
>
> Per
> http://www.latimes.com/news/science/la-sci-statins30aug30,0,7056171.story?coll=la-home-science
>
>
>

I address this in another post.

>
>>
>> It is still surprising to me that the statin worked that quickly. The
>> author of the study was also surprised. I don't understand what the
>> mechanism is.
>>
>> Bill
>>
>>> "Bill" <xxx@xxxxx> wrote in
>>> news:GyMQe.359$sF6.326@xxxxxxxxxxxxxxxxxxxxxxxxxx:
>>>
>>>> They are talking about giving this right after an MI. Surprising.
>>>>
>>>> Bill
>>>>
>>>> _______________________
>>>>
>>>>
>>>>
>>>> Statin drugs lower heart attack death-study
>>>> Mon Aug 29, 3:29 PM ET
>>>>
>>>> Giving a heart attack patient a statin drug right away reduces the
>>>> chance he or she will die by 50 percent, U.S. researchers said on
>>>> Monday.
>>>>
>>>> Statin drugs are used to lower cholesterol levels and prevent strokes
>>>> and heart attacks long-term, but the new study suggests that the drugs
>>>> might join aspirin as something to give to patients immediately when
>>>> they suffer a heart attack.
>>>>
>>>> "We've known that long-term statin therapy is beneficial, but this
>>>> study provides the strongest clinical evidence to date supporting the
>>>> early cardioprotective effects of statins immediately following a
>>>> heart attack," said cardiologist Dr. Gregg Fonarow of the University
>>>> of California, Los Angeles, who led the study.
>>>>
>>>> "As statins are already routinely started in myocardial infarction
>>>> patients prior to hospital discharge, it would be relatively easy to
>>>> administer this medication on arrival to the emergency department,"
>>>> Fonarow said in a statement.
>>>>
>>>> Fonarow and colleagues looked at the records of more than 170,000
>>>> heart attack patients.
>>>>
>>>> Those given statin drugs before hospitalization and within 24 hours
>>>> after a heart attack had a 54 percent lower risk of dying in the
>>>> hospital compared to patients not on statin therapy, they reported in
>>>> the September issue of the American Journal of Cardiology.
>>>>
>>>> Patients who had not been prescribed statins in the past but were
>>>> given one within 24 hours of hospitalization were 58 percent less
>>>> likely to die.
>>>>
>>>> "We were surprised that early statin therapy showed such a striking
>>>> effect immediately after a heart attack," Fonarow said. "We also found
>>>> that statins provided additional protection from other heart attack
>>>> complications as well."
>>>>
>>>> These complications included cardiac arrest, cardiac shock, cardiac
>>>> rupture and ventricular fibrillation.
>>>>
>>>> Statins lower cholesterol levels but they also affect the linings of
>>>> the blood vessels. They raise levels of nitric oxide, which in turn
>>>> may reduce the inflammation associated with heart attacks.
>>>>
>>>> The study was funded by Genentech Inc., which does not currently make
>>>> a statin drug but which helps support the registry of patients used
>>>> for the study, and Fonarow has done research for several companies
>>>> that make statins.
>>>>
>>>>
>>>>
>>>>
>>>
>>
>>
>
>


.

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