Re: statins and breast cancer

The other findings:

"Use of statins was associated with a decreased incidence of breast cancer
in woman >age50.

Women on HRT *and* a statin did not have an increased incidence of Breast
Cancer. Those receiving HRT without a statin developed breast cancer more
often, p<0.01."

[hmm, I seem to have missed the headlines reporting this to users."]

I've never felt everyone should take statins. Perhaps young women who have
no cad risk factors should consider not taking them.

L.

"eml" <mmlevy46@xxxxxxxxxxx> wrote in
news:1128644544.367517.312450@xxxxxxxxxxxxxxxxxxxxxxxxxxxx:

> http://www.asco.org/ac/1,1003,_12-002489-00_18-0023-00_19-00104183,00.a
> sp?AbstractID=104183&cat=&parent=&returnpid=
>
> Meeting: 2003 ASCO Annual Meeting Printer Friendly
> Bookmark
>
> Category: Cancer Prevention
> SubCategory: Early Clinical Trials
>
>
>
> Effect of statins on breast cancer incidence: Findings from the
> Sentara Health Plan.
> Abstract No: 373
> Citation: Proc Am Soc Clin Oncol 22: page 93, 2003 (abstr 373)
> Author(s): J. E. Mortimer, R. Axelrod, K. Zimbro; Sentara Norfolk
> General Hosp, Norfolk, VA
> Abstract: Statins are commonly employed to lower cholesterol. These
> agents have a theoretical role in chemoprevention through
> downregulation of Ras, upregulation of p27, and alteration in estrogen
> levels. We wished to determine if the use of statins had an impact on
> breast cancer incidence in women who participate in the Sentara Health
> Plan. A total of 66,843 women over 35 years are included in this
> analysis. Statin use was identified from pharmacy data available since
> 5/97. A total of 1512 cases of breast cancer were diagnosed, 273 who
> were taking statins for a mean of 9.3 months. Of the 8344 women taking
> statins, 273 developed breast cancer. The median age for women who
> were taking a statin but did not develop breast is 55.3 years; and is
> 57.6 years for those who developed breast cancer. The data were
> analyzed according to age: (Table) These data suggest that young women
> who are treated with statins may be at increased risk for the
> development of breast cancer.
>
>
>
>
> Associated Presentation(s):
>
> 1. Effect of statins on breast cancer incidence: Findings from the
> Sentara Health Plan.
> Event: 2003 ASCO Annual Meeting
> Presenter: Joanne E Mortimer, MD
> Session: Cancer Prevention
>

.

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